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首页> 外文期刊>Occupational and environmental medicine >Mortality and cancer morbidity in a cohort of Canadian petroleum workers.
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Mortality and cancer morbidity in a cohort of Canadian petroleum workers.

机译：一群加拿大石油工人的死亡率和癌症发病率。

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AIMS: To assess mortality and cancer morbidity in Canadian petroleum workers and explore exposure-response relations for specific petroleum agents. METHODS: A total of 25 292 employees hired between 1964 and 1994 were linked to the Canadian tumour registry and national mortality database. Exposure-response trends were assessed for hydrocarbon solvents/fuels, hydrocarbon lubricants, petroleum coke/spent catalyst, and hydrogen sulphide (H2S). RESULTS: External comparison analyses (mortality and incidence) showed deficits for all causes and all malignant neoplasms combined and were consistent with expectation for most malignant and non-malignant sites analysed. Gall bladder cancer mortality was increased among males based on four deaths, but cases had no common job assignments and the increase was focused in workers employed <10 years. Mesothelioma incidence was increased. Most exposure-specific analyses were compromised by small numbers. Statistically significant increases were observed for H2S exposure and a subgroup of accidental deaths as well as for petroleum coke/spent catalyst exposure and lung cancer. While both findings have a degree of biologic plausibility, the H2S association, which exhibited a clearer exposure-response pattern, could be subject to unmeasured confounders. Additionally, interpretation was complicated by the high correlation between hydrocarbon and H2S exposures. With regard to lung cancer, the analysis could not adequately control for smoking, was based on small numbers, and exhibited a tenuous exposure-response pattern. CONCLUSION: The findings for mesothelioma suggest the need for continued attention to asbestos in the petroleum industry. The relation between accidental deaths and H2S exposure deserves closer scrutiny in similarly exposed populations. Further analyses of lung cancer are underway and will be reported separately.
机译：目的：评估加拿大石油工人的死亡率和癌症发病率，并探讨特定石油代理人的暴露-反应关系。方法：在1964年至1994年之间雇用的25 292名员工与加拿大肿瘤登记系统和国家死亡率数据库相关联。评估了碳氢化合物溶剂/燃料，碳氢化合物润滑剂，石油焦/废催化剂和硫化氢（H2S）的暴露-响应趋势。结果：外部比较分析（死亡率和发生率）显示所有原因和所有恶性肿瘤合并存在缺陷，并且与大多数分析的恶性和非恶性部位的预期一致。男性的胆囊癌死亡率因四次死亡而增加，但该病例没有常见的工作任务，而这种增加的重点是受雇于<10年的工人。间皮瘤发病率增加。大多数特定于暴露的分析受到少量影响。硫化氢暴露和意外死亡的一个亚组以及石油焦/用过的催化剂暴露和肺癌在统计学上均显着增加。虽然这两个发现在一定程度上具有生物学上的合理性，但H2S协会表现出更清晰的暴露-反应模式，可能会受到无法衡量的混杂因素的影响。此外，碳氢化合物和H2S暴露之间的高度相关性使解释变得复杂。关于肺癌，该分析不能充分控制吸烟，其依据是数量少，并且显示出微弱的暴露-反应模式。结论：间皮瘤的发现表明在石油工业中需要继续关注石棉。在相似暴露的人群中，意外死亡与H2S暴露之间的关系值得进一步研究。肺癌的进一步分析正在进行中，将另行报告。

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