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首页> 外文期刊>Occupational and environmental medicine >Synergistic effect of hepatitis virus infection and occupational exposures to vinyl chloride monomer and ethylene dichloride on serum aminotransferase activity.
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Synergistic effect of hepatitis virus infection and occupational exposures to vinyl chloride monomer and ethylene dichloride on serum aminotransferase activity.

机译：肝炎病毒感染和职业性接触氯乙烯单体和二氯化乙烯对血清氨基转移酶活性的协同作用。

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AIMS: To study the synergistic effect of occupational chemical exposure and hepatitis virus infection on serum aminotransferase activity. METHODS: A total of 568 male workers who were employed in five polyvinyl chloride (PVC) or four vinyl chloride monomer (VCM) manufacturing factories were studied. Information relating to current job title, alcohol consumption, and cigarette smoking was obtained. Exposure level of chemical mixtures was classified by hygienic effect (a summation of personal time weighted average/reference permissible exposure level of each chemical) into high, moderate, and low exposure groups. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and anti-hepatitis C antibody were assayed. RESULTS: Hepatitis virus infection and increased body mass index were associated with abnormal serum aminotransferase activity. In workers with hepatitis virus infection, those with high exposure had a higher prevalence of abnormal AST and ALT compared to low exposure; among those without hepatitis virus infection, the differences of prevalence of abnormal AST and ALT were not significant between different chemical exposure groups. There was a significant trend of increasing risks of increased AST and ALT in moderate and high exposure groups with hepatitis virus infection. Such a synergistic effect was more prominent among HBeAg-positive workers. CONCLUSIONS: Mixed exposures to 1,2-ethylene dichloride and VCM have a positive synergistic effect with hepatitis virus infection on liver damage. Assessment of fitness for work should be considered in workers with hepatitis B and C infection, when they have potential exposure to hepatotoxins in the workplace.
机译：目的：研究职业化学暴露和肝炎病毒感染对血清氨基转移酶活性的协同作用。方法：研究了在五个聚氯乙烯（PVC）或四个氯乙烯单体（VCM）制造工厂工作的568名男性工人。获得了与当前职称，饮酒量和吸烟有关的信息。通过卫生效应（每种化学药品的个人时间加权平均值/参考允许的暴露水平的总和）将化学混合物的暴露水平分类为高，中和低暴露组。测定了血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT），乙型肝炎表面抗原（HBsAg），乙型肝炎e抗原（HBeAg）和抗丙型肝炎抗体。结果：肝炎病毒感染和体重指数升高与血清氨基转移酶活性异常有关。在肝炎病毒感染的工人中，高暴露者的AST和ALT异常发生率高于低暴露者。在未感染肝炎病毒的人群中，不同化学暴露组之间AST和ALT异常的发生率差异不显着。在肝炎病毒感染的中高暴露人群中，AST和ALT升高的风险呈显着上升趋势。这种协同效应在HBeAg阳性工人中更为突出。结论：混合暴露于1,2-二氯乙烷和VCM与肝炎病毒感染对肝损害有积极的协同作用。当乙型和丙型肝炎感染者可能在工作场所接触肝毒素时，应考虑是否适合工作。

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