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首页> 外文期刊>Occupational and environmental medicine >Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams.
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Percutaneous absorption of aromatic amines in rubber industry workers: impact of impaired skin and skin barrier creams.

机译：橡胶行业工人中芳香胺的经皮吸收：受损的皮肤和皮肤隔离膏的影响。

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BACKGROUND: Several aromatic amines (AA) could cause bladder cancer and are an occupational hygiene problem in the workplace. However, little is known about the percutaneous absorption of chemicals via impaired skin and about the efficacy of skin protection measures to reduce internal exposure. AIMS: To determine the impact of skin status and of skin protection measures on the internal exposure to AA in workers manufacturing rubber products. METHODS: 51 workers occupationally exposed to aniline and o-toluidine were examined. The workplace conditions, risk factors for skin and the use of personal protective equipment were assessed by means of a self-administered questionnaire. The skin of hands and forearms was clinically examined. Exposure to aniline and o-toluidine was assessed by ambient air and biological monitoring (analyses of urine samples and of haemoglobin adducts). RESULTS: Haemoglobin-AA-adduct levels in workers with erythema (73%) were significantly higher (p<0.04) than in workers with healthy skin (mean values: aniline 1150.4 ng/l vs 951.7 ng/l, o-toluidine 417.9 ng/l vs 118.3 ng/l). The multiple linear regression analysis showed that wearing gloves significantly reduced the internal exposure. A frequent use of skin barrier creams leads to a higher internal exposure of AA (p<0.03). However, the use of skincare creams at the workplace was associated with a reduced internal exposure (p<0.03). From these findings we assume that internal exposure of the workers resulted primarily from the percutaneous uptake. CONCLUSIONS: The study demonstrates a significantly higher internal exposure to AA in workers with impaired skin compared with workers with healthy skin. Daily wearing of gloves efficiently reduced internal exposure. However, an increased use of skin barrier creams enhances the percutaneous uptake of AA. Skincare creams seem to support skin regeneration and lead to reduced percutaneous uptake.
机译：背景：几种芳香胺（AA）可能导致膀胱癌，并且是工作场所的职业卫生问题。但是，对于经由受损的皮肤经皮吸收化学物质以及减少内部暴露的皮肤保护措施的功效知之甚少。目的：确定制造橡胶产品的工人的皮肤状况和皮肤保护措施对内部暴露于AA的影响。方法：对51名职业性接触苯胺和邻甲苯胺的工人进行了检查。工作场所条件，皮肤危险因素和个人防护设备的使用通过自我管理的问卷进行了评估。对手和前臂的皮肤进行了临床检查。通过环境空气和生物学监测（分析尿液样本和血红蛋白加合物）来评估苯胺和邻甲苯胺的暴露量。结果：红斑工人的血红蛋白-AA加合物水平（73％）显着高于健康皮肤工人（p <0.04）（平均值：苯胺1150.4 ng / l对951.7 ng / l，邻甲苯胺417.9 ng / l对118.3 ng / l）。多元线性回归分析表明，戴手套可以显着减少内部暴露。频繁使用皮肤隔离霜会导致较高的AA内部暴露（p <0.03）。但是，在工作场所使用护肤霜可减少内部暴露（p <0.03）。根据这些发现，我们认为工人的内部暴露主要是由于经皮摄取引起的。结论：该研究表明，皮肤受损的工人与健康皮肤的工人相比，AA内部暴露量明显更高。每天戴手套可以有效减少内部暴露。但是，增加使用皮肤屏障乳剂可提高AA的经皮吸收。护肤霜似乎可以促进皮肤再生并减少经皮吸收。

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