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首页> 外文期刊>Occupational and environmental medicine >Lung cancer and exposure to quartz and diesel exhaust in Swedish iron ore miners with concurrent exposure to radon.
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Lung cancer and exposure to quartz and diesel exhaust in Swedish iron ore miners with concurrent exposure to radon.

机译：瑞典铁矿工人的肺癌以及石英和柴油废气的暴露，并同时暴露于ra。

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OBJECTIVES: Studies of underground miners have documented an increased risk of lung cancer mainly linked to radon exposure but possibly influenced by other concurrent exposures. METHODS: A cohort study was carried out in 8321 iron ore miners with low exposure to radon, employed in 1923-1998 and followed up for lung cancer in 1958-2000. Historical exposures to radon, crystalline silica and diesel exhaust were assessed. Data including exposure to radon, quartz and diesel exhaust from another mine with higher exposure to radon were reanalysed. RESULTS: Miners had increased risk for lung cancer (SIR 1.48 (95% CI 1.22 to 1.78), based on 112 cases during 227,000 person-years). The increased risk could not be explained by exposure to radon or diesel exhaust but was associated with exposure to crystalline silica: SIR 0.96 (0.53 to 1.62), 1.45 (1.10 to 1.87), 1.99 (1.31 to 2.90) and 1.77 (0.92 to 3.10) in groups with exposure to 0, 0-2, 2-5 and >5 mg years/m3, respectively. Reanalysis of data from the other mine indicated that quartz was a possible confounder in the analysis of relationship between radon and lung cancer. In the highest radon exposed group, the point estimate for the RR decreased from 5.65 to 3.90 when adjusting for concurrent exposure to quartz. CONCLUSIONS: Crystalline silica, a known carcinogen, probably affects lung cancer risk in iron ore miners. The main implication of the results is for interpretation of the dose-response curve for radon and lung cancer in underground iron ore miners. Since exposure to radon and quartz is often correlated, quartz exposure can be an important confounder.
机译：目的：对地下矿工的研究表明，罹患肺癌的风险增加，这主要与ra暴露有关，但可能受到其他同时暴露的影响。方法：一项队列研究在1923年至1998年雇用的8321个ra含量低的铁矿工中进行，并于1958年至2000年进行了肺癌随访。评估了ra，结晶硅石和柴油机废气的历史暴露。重新分析了包括来自另一个矿山的ra，石英和柴油废气的数据，with的暴露程度更高。结果：矿工患肺癌的风险增加（基于227,000人年中的112例，SIR为1.48（95％CI为1.22至1.78））。暴露于ra气或柴油机废气无法解释增加的风险，但与暴露于结晶二氧化硅有关：SIR 0.96（0.53至1.62），1.45（1.10至1.87），1.99（1.31至2.90）和1.77（0.92至3.10） ）分别暴露于0、0-2、2-5和> 5 mg年/ m3的组。对另一座矿山数据的重新分析表明，石英是分析was与肺癌之间关系的可能混杂因素。在最高ra暴露组中，当调整同时暴露于石英时，RR的点估计值从5.65降至3.90。结论：结晶二氧化硅，一种已知的致癌物质，可能会影响铁矿石矿工患肺癌的风险。结果的主要含义是解释地下铁矿工中ra和肺癌的剂量反应曲线。由于often和石英的暴露通常是相关的，因此石英暴露可能是一个重要的混杂因素。

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