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首页> 外文期刊>Occupational and environmental medicine >Components of ambient air pollution affect thrombin generation in healthy humans: The RAPTES project
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Components of ambient air pollution affect thrombin generation in healthy humans: The RAPTES project

机译：RAPTES项目：环境空气污染的成分影响健康人类的凝血酶生成

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Objectives: Increases in ambient particulate matter (PM) have been associated with an elevated risk of stroke, myocardial ischaemia and coronary heart disease, with activation of blood coagulation likely playing an important role. PM-mediated activation of two major activation pathways of coagulation provides a potential mechanism for the observed association between PM and cardiovascular disease. However, it remains unclear which specific characteristics and components of air pollution are responsible. Methods: In order to investigate those characteristics and components, we semiexperimentally exposed healthy adult volunteers at fi ve different locations with increased contrasts and reduced correlations among PM characteristics. Volunteers were exposed for 5 h, exercising intermittently, 3-7 times at different sites from March to October 2009. On site, we measured PM mass and number concentration, its oxidative potential (OP), content of elemental/organic carbon, trace metals, sulphate, nitrate and gaseous pollutants (ozone, nitrogen oxides). Before and 2 and 18 h after exposure we sampled blood from the participants and measured thrombin generation using the calibrated automated thrombogram. Results: We found that thrombin generation increases in the intrinsic (FXII-mediated) blood coagulation pathway in relation to ambient air pollution exposure. The associations with NO2, nitrate and sulphate were consistent and robust, insensitive to adjustment for other pollutants. The associations with tissue factor-mediated thrombogenicity were not very consistent. Conclusions: Ex vivo thrombin generation was associated with exposure to NO2, nitrate and sulphate, but not PM mass, PM OP or other measured air pollutants.
机译：目标：周围颗粒物（PM）的增加与中风，心肌缺血和冠心病的风险升高有关，凝血的激活可能起重要作用。 PM介导的凝血的两个主要激活途径的激活为PM和心血管疾病之间的关联提供了潜在的机制。但是，尚不清楚造成空气污染的具体特征和成分。方法：为了研究这些特征和组成部分，我们半实验地暴露了健康成人志愿者在五个不同位置的情况，这些特征的对比度增加且PM特征之间的相关性降低。从2009年3月至2009年10月，志愿者在不同地点进行5小时间歇性运动3至7次。在现场，我们测量了PM的质量和数量浓度，其氧化电位（OP），元素/有机碳含量，微量金属，硫酸盐，硝酸盐和气态污染物（臭氧，氮氧化物）。在暴露之前，暴露后2小时和18小时，我们从参与者那里采集血液，并使用校准的自动血栓图测量凝血酶的产生。结果：我们发现与环境空气污染暴露相关的内在（FXII介导的）血液凝血途径中凝血酶的生成增加。与NO2，硝酸盐和硫酸盐的关联是一致且稳健的，对其他污染物的调整不敏感。与组织因子介导的血栓形成的关系不是很一致。结论：离体凝血酶的产生与暴露于NO2，硝酸盐和硫酸盐有关，但与PM质量，PM OP或其他测量的空气污染物无关。

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