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首页> 外文期刊>Occupational and environmental medicine >Mould and dampness in dwelling places, and onset of asthma: The population-based cohort ECRHS
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Mould and dampness in dwelling places, and onset of asthma: The population-based cohort ECRHS

机译：居住地区的霉菌和潮湿以及哮喘的发作：基于人群的队列ECRHS

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Objectives: To study new onset of adult asthma in relation to dampness and moulds in dwelling places. Methods: Totally, 7104 young adults from 13 countries who participated in the European Community Respiratory Health Survey (ECRHS I and II) who did not report respiratory symptoms or asthma at baseline were followed prospectively for 9 years. Asthma was assessed by questionnaire data on asthmatic symptoms and a positive metacholine challenge test at follow-up. Data on the current dwelling was collected at the beginning and at the end of the follow-up period by means of an interviewer-led questionnaire, and by inspection. Relative risks (RR) for new onset asthma were calculated with log-binomial models adjusted for age, sex, smoking and study centre. Results: There was an excess of new asthma in subjects in homes with reports on water damage (RR 1.46; 95% CI 1.09 to 1.94) and indoor moulds (RR=1.30; 95% CI 1.00 to 1.68) at baseline. A dose-response effect was observed. The effect was stronger in those with multisensitisation and in those sensitised to moulds. Observed damp spots were related to new asthma (RR=1.49; 95% CI 1.00 to 2.22). The population-attributable risk was 3-10% for reported, and 3-14% for observed dampness/moulds. Conclusions: Dampness and mould are common in dwellings, and contribute to asthma incidence in adults.
机译：目的：研究与居住环境中的湿气和霉菌有关的成人哮喘的新发病例。方法：总共对来自13个国家的7104名年轻人进行了为期9年的调查，这些年轻人参加了欧洲共同体呼吸健康调查（ECRHS I和II），在基线时未报告呼吸道症状或哮喘。哮喘通过问卷调查数据评估哮喘症状，并在随访时进行了阳性胆碱激发试验。在随访期间的开始和结束时，通过访问员领导的问卷调查和检查收集了有关当前住所的数据。使用针对年龄，性别，吸烟和研究中心进行调整的对数二项式模型，计算新发哮喘的相对风险（RR）。结果：基线时，房屋中有大量新哮喘患者，报告有水损害（RR 1.46; 95％CI 1.09至1.94）和室内霉菌（RR = 1.30; 95％CI 1.00至1.68）。观察到剂量反应作用。在具有多敏化作用的人和对霉菌敏感的人中，效果更强。观察到的湿点与新发哮喘有关（RR = 1.49; 95％CI 1.00至2.22）。报告的人群归因风险为3-10％，观察到的潮湿/霉菌为3-14％。结论：潮湿和发霉在住宅中很常见，并且会导致成年人患哮喘。

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