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首页> 外文期刊>Occupational and environmental medicine >Occupations and exposures in the work environment as determinants for rheumatoid arthritis.
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Occupations and exposures in the work environment as determinants for rheumatoid arthritis.

机译：工作环境中的职业和暴露是类风湿关节炎的决定因素。

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BACKGROUND AND AIMS: Several occupational categories have been associated with rheumatoid arthritis (RA); this study was conducted to further evaluate these associations. METHODS: Lifelong occupational history together with exposure experiences were collected through a postal questionnaire answered by 293 incident cases and 1346 population based referents. Occupational determinants were evaluated through stratified and multivariate analyses; pooled analyses with previously gathered data on 422 prevalent cases and 858 referents were also performed. RESULTS: In both materials, significantly increased logistic odds ratios (LORs) were seen for male conductors, freight and transport workers (LOR 17.8, 95% CI 1.5 to 207.8 and LOR 4.7, 95% CI 1.4 to 16.3, respectively), and farmers and farm workers (LOR 2.4, 95% CI 1.1 to 5.2, and LOR 2.2, 95% CI 1.3 to 3.5, respectively). Among women, increased LORs were seen in the separate and the pooled material for printmakers and process engravers (LOR 5.5, 95% CI 0.9 to 32.6, and LOR 3.0, 95% CI 0.9 to 10.3, respectively). Increased risks were seen in both materials for men exposed to asbestos (LOR 2.5, 95% CI 1.0 to 6.8, and LOR 1.6, 95% CI 0.8 to 3.3, respectively), and vibrations (LOR 2.0, 95% CI 0.9 to 4.4, and LOR 2.2, 95% CI 1.3 to 3.8, respectively). The risk for RA increased with increasing duration of exposure to vibrations and mineral dust, respectively. CONCLUSIONS: There was evidence of a causal relation between exposures to vibrations and mineral dust and development of RA among men. Occupational factors seem to be aetiologically more important for men, and most occupations at risk involve multiple exposures. Several exposures associated with an increased risk for RA are frequent among farmers, and some of the occupations at risk include exposure to organic dust.
机译：背景与目的：类风湿关节炎（RA）与多种职业有关。进行这项研究以进一步评估这些关联。方法：通过邮寄问卷收集了293例事件病例和1346例基于人群的被访者，收集了终身职业经历和接触经历。通过分层和多元分析评估职业决定因素。还对先前收集的关于422个流行病例和858个对象的数据进行了汇总分析。结果：在两种材料中，男性指挥员，货运和运输工人的物流比值比（LOR）均显着提高（LOR 17.8，95％CI 1.5至207.8和LOR 4.7，95％CI 1.4-16.3）和农民和农场工人（分别为LOR 2.4、95％CI 1.1至5.2和LOR 2.2、95％CI 1.3至3.5）。在女性中，在单独的和合并的版画家和制版机用材料中，看到的LOR升高（分别为LOR 5.5、95％CI 0.9至32.6和LOR 3.0、95％CI 0.9至10.3）。两种材料中暴露于石棉的男性（分别为LOR 2.5、95％CI 1.0至6.8和LOR 1.6、95％CI 0.8至3.3）和振动（LOR 2.0、95％CI 0.9至4.4，和LOR 2.2，95％CI 1.3到3.8）。 RA的风险分别随着暴露于振动和矿物粉尘的持续时间的增加而增加。结论：有证据表明男性遭受振动和矿物粉尘的暴露与RA的发展之间存在因果关系。在男性上，职业因素在病因学上似乎更为重要，大多数处于危险中的职业涉及多次接触。农民中经常发生几种与RA风险增加相关的暴露，某些处于危险中的职业包括接触有机粉尘。

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