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首页> 外文期刊>Occupational and environmental medicine >NO2 and children's respiratory symptoms in the PATY study.
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NO2 and children's respiratory symptoms in the PATY study.

机译：PATY研究中的NO2和儿童的呼吸道症状。

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OBJECTIVES: NO2)is a major urban air pollutant. Previously reported associations between ambient NO2)and children's respiratory health have been inconsistent, and independent effects of correlated pollutants hard to assess. The authors examined effects of NO2 on a spectrum of 11 respiratory symptoms, controlling for PM10 and SO2, using a large pooled dataset. METHODS: Cross sectional studies were conducted in Russia, Austria, Italy, Switzerland, and the Netherlands, during 1993-99, contributing in total 23 955 children. Study-specific odds ratios for associations with ambient NO2 are estimated using logistic regressions with area-level random effects. Heterogeneity between study-specific results, and mean estimates (allowing for heterogeneity) are calculated. RESULTS: Long term average NO2 concentrations were unrelated to prevalences of bronchitis or asthma. Associations were found for sensitivity to inhaled allergens and allergy to pets, with mean odds ratios around 1.14 per 10 microg/m3 NO2. SO2 had little confounding effect, but an initial association between NO2 and morning cough was reduced after controlling for PM10. Associations with reported allergy were not reduced by adjustment for the other pollutants. Odds ratios for allergic symptoms tended to be higher for the 9-12 year old children compared with the 6-8 year old children. CONCLUSIONS: Evidence for associations between NO2 and respiratory symptoms was robust only for inhalation allergies. NO2 most likely is acting as an indicator of traffic related air pollutants, though its direct effect cannot be ruled out. This remains important, as policies to reduce traffic related air pollution will not result in rapid reductions.
机译：目标：NO2）是主要的城市空气污染物。先前报道的环境NO2）与儿童呼吸健康之间的关联一直不一致，并且难以评估相关污染物的独立影响。作者使用一个大型汇总数据集检查了NO2对11种呼吸道症状的影响，控制了PM10和SO2。方法：在1993-99年期间，在俄罗斯，奥地利，意大利，瑞士和荷兰进行了横断面研究，总共为23 955名儿童提供了帮助。使用具有区域级随机效应的逻辑回归估计与环境NO2关联的研究特定优势比。计算特定于研究的结果与均值（允许异质性）之间的异质性。结果：长期平均NO2浓度与支气管炎或哮喘的患病率无关。发现对吸入性过敏原的敏感性和对宠物的过敏性的关联，平均比值比约为每10微克/立方米NO2 1.14。 SO2几乎没有混杂作用，但控制PM10后，NO2和晨咳之间的初始联系减少了。通过调整其他污染物并没有减少与已报告过敏相关的组织。 9至12岁儿童的过敏症状几率比6至8岁儿童更高。结论：仅对于吸入性变态反应，NO 2与呼吸道症状之间关联的证据很充分。尽管不能排除其直接影响，但NO2很可能是与交通有关的空气污染物的指标。这一点很重要，因为减少交通相关空气污染的政策不会导致迅速减少。

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