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首页> 外文期刊>Occupational and environmental medicine >Occupational risk factors for pancreatic cancer among female textile workers in Shanghai, China.
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Occupational risk factors for pancreatic cancer among female textile workers in Shanghai, China.

机译：中国上海女性纺织工人中胰腺癌的职业危险因素。

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摘要

OBJECTIVES: To investigate whether occupational exposures to dusts and chemicals in the Shanghai textile industry are associated with risk of pancreatic cancer. METHODS: A case cohort study nested in a cohort of 267,400 female textile workers in Shanghai, China was conducted among 180 incident pancreatic cancer cases and an age stratified randomly selected comparison subcohort (n = 3188). A complete occupational history of work in the textile industry was obtained for each woman, and was linked to a job exposure matrix developed for the textile industry to estimate exposures to specific dusts and chemicals. Cumulative exposures to cotton dust and endotoxin were reconstructed from historical and contemporaneous measurements. RESULTS: After adjusting for smoking status, a trend of decreasing risk of pancreatic cancer was observed for increasing cumulative exposures to cotton dust and endotoxin with a lag of 20 years. The hazard ratios for women cumulatively exposed to >143.4 mg/m3 x years of cotton dust and >3530.6 EU/m3 x years of endotoxin were 0.6 (95% CI 0.3 to 0.9) and 0.5 (95% CI 0.3 to 0.9), respectively, compared to unexposed women. There was little evidence that exposures to other textile dusts and chemicals were associated with risk of pancreatic cancer. CONCLUSIONS: Occupational exposure to cotton dust and endotoxin in the textile industry may have reduced risks of pancreatic cancer in this cohort. These associations should be replicated by others before making a firm conclusion of their possible effects on pancreatic cancer.
机译：目的：调查上海纺织工业中职业性接触粉尘和化学药品是否与胰腺癌风险相关。方法：在中国上海的267400名女性纺织工人队列中进行了一项病例队列研究，该队列是在180例胰腺癌和年龄分层的随机选择的比较亚队列中进行的（n = 3188）。获得了每位女性在纺织业的完整职业工作史，并将其与为纺织业开发的工作暴露矩阵相联系，以估计特定粉尘和化学物质的暴露。从历史和同期的测量值可以得出累积的棉尘和内毒素暴露量。结果：在调整了吸烟状况后，观察到胰腺癌风险的趋势是随着棉尘和内毒素的累积暴露而增加，且滞后20年。累积暴露于> 143.4 mg / m3 x年的棉尘和> 3530.6 EU / m3 x年的内毒素的女性的危险比分别为0.6（95％CI 0.3至0.9）和0.5（95％CI 0.3至0.9） ，相比未暴露的女性。几乎没有证据表明暴露于其他纺织品的粉尘和化学物质与胰腺癌的风险有关。结论：在该行业中，职业接触棉尘和内毒素可能降低了胰腺癌的风险。在确定它们对胰腺癌的可能影响之前，应将这些关联复制给其他人。

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