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首页> 外文期刊>Occupational and environmental medicine >Effect of different approaches to treatment of smoking as a potential confounder in a case-control study on occupational exposures.
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Effect of different approaches to treatment of smoking as a potential confounder in a case-control study on occupational exposures.

机译：在职业暴露的病例对照研究中，不同方法作为潜在的混杂因素治疗吸烟的效果。

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AIM: To evaluate the effect of different approaches to treatment of smoking as a potential confounder in an occupational study of lung cancer. METHODS: Data were used from a case-control study on 956 men with lung cancer and 1253 population controls recruited in two northern Italian areas during 1990-1992. The risk of lung cancer associated with 11 selected job titles and eight selected industrial activities was estimated using seven different methods to treat smoking history. To evaluate the confounding effect of smoking, odds ratios obtained using the first six models were compared with estimates from the seventh and most complex model, in which cumulative tobacco consumption and time since cessation were considered. RESULTS: Although crude odds ratios for some of the occupational categories were biased by up to 25%, such bias decreased to less than 10% when a simple model including smoking status (never, ex-, current) was used. CONCLUSIONS: In occupational studies on lung cancer risk, information onsmoking status may allow satisfactory control of the potential confounding effect of the habit.
机译：目的：在肺癌的一项职业研究中，评估不同治疗方法作为潜在混杂因素的效果。方法：采用病例对照研究的数据，研究对象是1990年至1992年在意大利北部两个地区招募的956名男性肺癌患者和1253名人口对照患者。使用七种不同的治疗吸烟史的方法，估计了与11种选定工作职位和8种选定工业活动相关的肺癌风险。为了评估吸烟的混杂效应，将使用前六个模型获得的优势比与第七个也是最复杂的模型的估计值进行比较，在第七个模型中，考虑了累积的烟草消费量和自戒烟以来的时间。结果：尽管某些职业类别的原油比值率偏差高达25％，但是当使用包括吸烟状态（从不，既往，当前）的简单模型时，这种偏差降低到小于10％。结论：在有关肺癌风险的职业研究中，关于吸烟状况的信息可能可以令人满意地控制该习惯的潜在混杂效应。

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