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首页> 外文期刊>Occupational and environmental medicine >Exposure to welding fumes is associated with acute systemic inflammatory responses.
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Exposure to welding fumes is associated with acute systemic inflammatory responses.

机译：暴露于焊接烟雾与急性全身性炎症反应有关。

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AIMS: To investigate the acute systemic inflammatory response to welding fume exposure. METHODS: Twenty four welders (42% smokers) and 13 non-exposed controls (23% smokers) were monitored at a welding school. Exposure to fine particulate matter (PM2.5) was assessed using cyclone samplers. Markers of systemic inflammation, including C-reactive protein (CRP), fibrinogen, and white blood cell (WBC) levels, were determined in peripheral blood samples collected at baseline and after 5.3 (SD 1.0) hours of exposure. RESULTS: The median PM2.5 concentration for welders was 1.66 mg/m3, which was significantly greater than that for controls (0.04 mg/m3). Compared to non-smokers, smokers had a significantly higher baseline WBC count, but comparable levels of CRP and fibrinogen. In non-smokers, welding fume exposure was associated with a significant increase in WBC and neutrophil counts immediately following exposure (+0.8x10(3)/mul, 95% CI 0.1 to 1.6, and +1.0x10(3)/mul, 95% CI 0.4 to 1.7, respectively). A significant decrease in fibrinogen levels was observed in non-smokers (-32 mg/dl, 95% CI -63 to -1). No significant changes in WBC, neutrophil, and fibrinogen levels were found in smokers. Sixteen hours after welding exposure, CRP levels were found to be significantly increased in both non-smokers and smokers (0.90 mg/l, 95% CI 0.17 to 1.64). PM2.5 concentrations were found to be significantly associated with absolute neutrophil counts in non-smokers, and CRP levels in both non-smokers and smokers. CONCLUSIONS: High levels of welding fume exposure induce acute systemic inflammation in a relatively young, healthy working population. These results also suggest that smoking may modify the effect of welding fume exposure on specific inflammatory markers.
机译：目的：研究对焊烟暴露的急性全身炎症反应。方法：在一所焊接学校对二十四名焊工（42％的吸烟者）和13名未暴露的对照组（23％的吸烟者）进行了监测。使用旋风取样器评估暴露于细颗粒物（PM2.5）。在基线和暴露后5.3（SD 1.0）小时后收集的外周血样本中确定了全身炎症标志物，包括C反应蛋白（CRP），纤维蛋白原和白细胞（WBC）水平。结果：焊工的PM2.5浓度中位数为1.66 mg / m3，明显高于对照组的0.02.5 mg / m3。与不吸烟者相比，吸烟者的基线白细胞计数显着更高，但CRP和纤维蛋白原水平却相当。在非吸烟者中，焊烟暴露与暴露后立即增加WBC和嗜中性白血球数量有关（+ 0.8x10（3）/ mul，95％CI 0.1至1.6，和+ 1.0x10（3）/ mul，95 ％CI分别为0.4至1.7）。在非吸烟者中血纤蛋白原水平显着下降（-32 mg / dl，95％CI -63至-1）。在吸烟者中，白细胞，中性粒细胞和纤维蛋白原水平没有明显变化。焊接暴露十六小时后，发现非吸烟者和吸烟者的CRP水平均显着升高（0.90 mg / l，95％CI 0.17至1.64）。发现PM2.5浓度与非吸烟者的绝对嗜中性白血球数量显着相关，并且与非吸烟者和吸烟者的CRP水平显着相关。结论：高水平的焊接烟雾暴露在相对年轻，健康的工作人群中引起急性全身性炎症。这些结果还表明，吸烟可能会改变电焊烟暴露对特定炎症标志物的影响。

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