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首页> 外文期刊>Occupational and environmental medicine >Could mining be protective against prostate cancer? A study and literature review.
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Could mining be protective against prostate cancer? A study and literature review.

机译：采矿可以预防前列腺癌吗？研究和文献综述。

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OBJECTIVE: Prostate cancer is one of the most commonly diagnosed cancers in Western men and one in three Australian men develops the cancer before the age of 75. Currently, only increasing age, race and family history have been well established as risk factors. A growing number of studies have investigated occupation in relation to prostate cancer but, like other risk factors, no associations have been confirmed. Mining employs a significant proportion of the work force in Western Australia. The aims of this study were to describe the characteristics of miners in the Western Australian Prostate Health Study, investigate mining as a risk factor for prostate cancer, conduct a systematic search of the literature for studies that have investigated mining as an occupational risk factor for prostate cancer and compare and contrast their methodologies and results. METHODS: Data were obtained from a population-based case-control study conducted from 1 January 2001 to 20 August 2002 at The University of Western Australia. RESULTS: After controlling for age, family history and military service in Vietnam, miners had a statistically significantly reduced risk of prostate cancer (adjusted OR 0.35, 95% CI 0.16 to 0.75). The systematic literature search of studies examining mining and prostate cancer found a reasonably consistent trend of a decreased risk of prostate cancer among miners. None of the published articles discussed their results regarding mining and prostate cancer in detail, and a biological mechanism to support these results has not previously been suggested. CONCLUSION: The relationship between mining and prostate cancer deserves further investigation.
机译：目的：前列腺癌是西方男性中最常被诊断出的癌症之一，三分之一的澳大利亚男性在75岁之前罹患了这种癌症。目前，只有年龄，种族和家族史的增加才是危险因素。越来越多的研究调查了与前列腺癌有关的职业，但是，与其他危险因素一样，尚未确定任何关联。采矿业在西澳大利亚州雇用了很大一部分劳动力。这项研究的目的是在西澳大利亚州前列腺健康研究中描述矿工的特征，调查采矿是前列腺癌的危险因素，系统地检索文献以研究采矿是前列腺癌的职业危险因素癌症并比较和对比他们的方法和结果。方法：数据来自于2001年1月1日至2002年8月20日在西澳大利亚大学进行的基于人群的病例对照研究。结果：在控制了越南的年龄，家族史和服兵役之后，矿工的前列腺癌风险有统计学上的显着降低（调整后的OR为0.35，95％CI为0.16至0.75）。对研究采矿和前列腺癌的研究进行系统的文献检索发现，矿工患前列腺癌的风险呈合理一致的趋势。没有一篇发表的文章详细讨论了他们关于采矿和前列腺癌的结果，并且以前没有提出支持这些结果的生物学机制。结论：采矿与前列腺癌之间的关系值得进一步研究。

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