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首页> 外文期刊>Occupational and environmental medicine >Possible effect of environmental exposure to asbestos on geographical variation in mesothelioma rates.
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Possible effect of environmental exposure to asbestos on geographical variation in mesothelioma rates.

机译：环境暴露于石棉可能对间皮瘤发生率的地理变化产生影响。

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BACKGROUND: In population-based mesothelioma studies in industrialised countries, the incidence of mesothelioma without any identified asbestos exposure (IAE) is usually higher among women, while male incidence is mainly attributed to IAE. Through a comparison of the spatial distribution of male and female rates, and IAE and no IAE incidence, this study investigated whether mesotheliomas without IAE are in fact induced by non-recognised asbestos exposure, mostly from environmental sources. METHODS: We calculated mesothelioma mortality (SMR) and incidence (SIR) ratios by district in France, pooling 30 and 10 years of data, respectively. Using correlation coefficients, we compared geographical patterns of male and female mesothelioma ratios, and IAE and no IAE mesothelioma ratios. RESULTS: The raw numbers of male and female mesothelioma cases were equivalent. Mesothelioma SMR (0.76) and SIR (0.80) geographical correlations between men and women were strongly positive. SIR correlation between occupationally IAE and no IAE cases was also positive (0.69). Correlation between occupationally IAE and no IAE cases was positive among women but not among men. CONCLUSIONS: Data analyses of mesothelioma mortality and incidence showed that female cases occur in the same geographical areas as male cases. Female mesotheliomas with no IAE occur in the same geographical areas as exposed cases, suggesting asbestos has a major influence on female mesothelioma, likely through environmental exposure.
机译：背景：在工业化国家基于人群的间皮瘤研究中，女性间皮瘤的发病率通常较高，而没有任何确定的石棉暴露（IAE），而男性的发病率主要归因于IAE。通过比较男性和女性比率的空间分布以及IAE和无IAE发生率，本研究调查了没有IAE的间皮瘤实际上是否是由未识别的石棉暴露引起的，主要是来自环境来源。方法：我们按法国地区计算了间皮瘤死亡率（SMR）和发病率（SIR）比率，分别收集了30年和10年的数据。使用相关系数，我们比较了男性和女性间皮瘤比率，IAE和无IAE间皮瘤比率的地理模式。结果：男女间皮瘤病例的原始数量是相等的。男女之间的间皮瘤SMR（0.76）和SIR（0.80）地理相关性很强。职业性IAE与无IAE病例之间的SIR相关性也为正值（0.69）。职业IAE与无IAE病例之间的相关性在女性中是阳性的，但在男性中不是。结论：间皮瘤死亡率和发病率的数据分析表明，女性病例与男性病例发生在相同的地理区域。没有IAE的女性间皮瘤与暴露病例发生在相同的地理区域，这表明石棉可能通过环境暴露对女性间皮瘤产生重大影响。

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