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首页> 外文期刊>Occupational and environmental medicine >Atrazine in municipal drinking water and risk of low birth weight, preterm delivery, and small-for-gestational-age status.
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Atrazine in municipal drinking water and risk of low birth weight, preterm delivery, and small-for-gestational-age status.

机译：市政饮用水中的r去津和低出生体重，早产和小胎龄的风险。

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BACKGROUND: Atrazine is a herbicide used extensively worldwide. Bioassays have shown that it is embryotoxic and embryolethal. Evidence of adverse reproductive outcomes from exposure in the general population is sparse. AIMS: To evaluate the association between atrazine levels in municipal drinking water and the following adverse reproductive outcomes: increased risk of preterm delivery, low birth weight (LBW), and small-for-gestational-age (SGA) status. METHODS: A total of 3510 births that took place from 1 October 1997, to 30 September 1998 were analysed. Atrazine measurements were available for 2661 samples from water treatment plants over the past decade. A seasonal pattern was identified, with atrazine peaking from May to September. The geometric mean of the atrazine level for this period was calculated for each water distribution unit and merged with the individual data by municipality of residence. RESULTS: Atrazine levels in water were not associated with an increased risk of LBW or SGA status and were slightly associated with prematurity. There was an increased risk of SGA status in cases in which the third trimester overlapped in whole or in part with the May-September period, compared with those in which the third trimester occurred totally from October to April (OR = 1.37, 95% CI 1.04 to 1.81). If the entire third trimester took place from May to September, the OR was 1.54 (95% CI 1.11 to 2.13). CONCLUSIONS: Low levels of atrazine, a narrow exposure range, and limitations in the exposure assessment partly explain the lack of associations with atrazine. Findings point to the third trimester of pregnancy as the potential vulnerable period for an increased risk of SGA birth. Exposures other than atrazine and also seasonal factors may explain the increased risk.
机译：背景：阿特拉津是世界范围内广泛使用的除草剂。生物测定表明，它具有胚胎毒性和致死性。普通人群中因接触不良生殖结果的证据很少。目的：评估城市饮用水中at去津水平与以下不良生殖结果之间的关联：早产风险增加，低出生体重（LBW）和小胎龄（SGA）状态。方法：对1997年10月1日至1998年9月30日的3510例婴儿进行了分析。在过去十年中，可从水处理厂获得2661个样品的去津含量。确定了季节性模式，at去津在5月至9月达到峰值。对于每个水分配单元，计算该时期period去津水平的几何平均值，并根据居住城市将其与个人数据合并。结果：水中At去津水平与LBW或SGA状态的风险增加无关，而与早产稍有相关。相比于10月至4月的整个三个月的孕晚期，与三个月的孕期完全或部分重叠的孕晚期，全部或部分重叠的病例发生SGA的风险增加（OR = 1.37，95％CI 1.04至1.81）。如果整个5月至9月都处于孕晚期，则OR为1.54（95％CI 1.11至2.13）。结论：阿特拉津水平低，暴露范围狭窄以及暴露评估的局限性部分解释了与阿特拉津缺乏关联的原因。研究结果表明，妊娠晚期是可能增加SGA出生风险的潜在脆弱时期。除了阿特拉津以外的其他暴露以及季节性因素也可以解释风险的增加。

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