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首页> 外文期刊>Occupational and environmental medicine >Association of ventricular arrhythmias detected by implantable cardioverter defibrillator and ambient air pollutants in the St Louis, Missouri metropolitan area.
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Association of ventricular arrhythmias detected by implantable cardioverter defibrillator and ambient air pollutants in the St Louis, Missouri metropolitan area.

机译：在密苏里州圣路易斯市，通过植入式心脏复律除颤器检测到的室性心律失常与周围空气污染物的关联。

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摘要

BACKGROUND: It has previously been reported that the risk of ventricular arrhythmias is positively associated with ambient air pollution among patients with implantable cardioverter defibrillators (ICD) in Boston. AIMS: To assess the association of community exposures to air pollution with ventricular arrhythmias in a cohort of ICD patients in metropolitan St Louis, Missouri. METHODS: ICD detected episodes reported during clinical follow up were abstracted and reviewed by an electrophysiologist to identify ventricular arrhythmias. A total of 139 ventricular arrhythmias were identified among 56 patients. A case-crossover design was used with control periods matched on weekday and hour of the day within the same calendar month. Conditional logistic regression models were adjusted for temperature, barometric pressure, and relative humidity in the 24 hours preceding the event. RESULTS: There was a significant (24%, 95% CI 7% to 44%) increase in risk of ventricular arrhythmias associated with each 5 ppb increase in mean sulphur dioxide and non-significantly increased risk (22%, 95% CI -6% to 60%; and 18%, 95% CI -7% to 50%) associated with increases in nitrogen dioxide (6 ppb) and elemental carbon (0.5 microg/m3), respectively in the 24 hours before the arrhythmia. CONCLUSIONS: These results provide evidence of an association between ventricular arrhythmias and ambient air pollutants in St Louis. This is consistent with previous results from Boston, although the pollutants responsible for the increased risk are different.
机译：背景：以前有报道说，波士顿植入式心脏复律除颤器（ICD）患者的室性心律失常风险与周围空气污染呈正相关。目的：评估密苏里州大都会圣路易斯市的一群ICD患者的社区空气污染暴露与室性心律失常的相关性。方法：将临床随访期间报告的ICD检测出的发作摘要并由电生理学家进行复查，以识别室性心律失常。在56例患者中共鉴定出139例室性心律失常。使用案例交叉设计，控制周期在同一日历月的工作日和一天中的小时匹配。在事件发生前的24小时内，对温度，大气压力和相对湿度进行了条件Logistic回归模型的调整。结果：平均二氧化硫每增加5 ppb，室性心律失常的风险显着增加（24％，95％CI 7％至44％），风险显着增加（22％，95％CI -6在心律不齐之前的24小时内，分别导致二氧化氮（6 ppb）和元素碳（0.5 microg / m3）增加的百分比分别为50％至60％，18％，95％CI -7％至50％。结论：这些结果提供了心律失常与圣路易斯环境空气污染物之间的关联的证据。这与波士顿先前的结果一致，尽管造成风险增加的污染物有所不同。

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