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首页> 外文期刊>Occupational and environmental medicine >Sensitisation to enzymes in the animal feed industry.
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Sensitisation to enzymes in the animal feed industry.

机译：在动物饲料工业中对酶的敏化作用。

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OBJECTIVES: To assess the prevalence of enzyme sensitisation in the animal feed industry. METHODS: A cross sectional study was conducted in four animal feed factories, where several enzymes had been used in powder form for 7-9 years. Before this study, enzymes in liquid form had started to be used. Sensitisation to enzymes was examined by skin prick and radioallergosorbent (RAST) tests. Altogether 218 workers were tested; 140 people in various tasks in manufacturing, where exposure to various organic dusts and to enzymes was possible, and 78 non-exposed office workers. The workers were interviewed for work related respiratory and skin symptoms. Total dust concentrations were measured by a gravimetric method. The concentrations of protease and alpha-amylase were measured with catalytic methods and that of xylanase with an immunological method. RESULTS: Ten workers (7%) were sensitised to enzymes in the exposed group of 140, whereas none were sensitised in the non-exposed group. Six of the sensitised people had respiratory symptoms at work: two of them especially in connection with exposure to enzymes. Enzyme concentrations in the air varied greatly: xylanase from less than 0.8 ng/m(3) up to 16 ng/m(3), alpha-amylase from less than 20 ng/m(3) up to 200 ng/m(3), and protease from less than 0.4 ng/m(3)up to 2900 ng/m(3). On average, highest xylanase and alpha-amylase concentrations were found in the various manufacturing sites, whereas the highest protease concentrations were found in areas of high total dust. CONCLUSIONS: Industrial enzymes may cause allergies in the animal feed industry. There is a need to assess exposure to enzymes at various phases of production, and to minimise exposures.
机译：目的：评估动物饲料工业中酶敏化的发生率。方法：在四个动物饲料工厂进行了横断面研究，其中几种酶以粉末形式使用了7-9年。在这项研究之前，液态酶已开始使用。通过皮肤点刺和放射性过敏吸附（RAST）测试检查对酶的敏感性。总共对218名工人进行了测试; 140名从事制造工作的人员（可能接触各种有机粉尘和酶）和78名未暴露的上班族。工人接受了与工作有关的呼吸道和皮肤症状的采访。总灰尘浓度通过重量分析法测量。用催化方法测定蛋白酶和α-淀粉酶的浓度，用免疫学方法测定木聚糖酶的浓度。结果：140名暴露组中有10名工人（占7％）对酶敏感，而未暴露组中没有一名工人对酶敏感。六个过敏的人在工作时出现呼吸道症状：其中两个特别是与酶接触有关。空气中的酶浓度变化很大：木聚糖酶从小于0.8 ng / m（3）到16 ng / m（3），α-淀粉酶从小于20 ng / m（3）到200 ng / m（3） ）和小于0.4 ng / m（3）的蛋白酶至2900 ng / m（3）。平均而言，在各个生产地点发现了最高的木聚糖酶和α-淀粉酶浓度，而在总灰尘较高的地区发现了最高的蛋白酶浓度。结论：工业酶可能在动物饲料工业中引起过敏。需要评估生产的各个阶段对酶的暴露，并尽量减少暴露。

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