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首页> 外文期刊>Occupational and environmental medicine >A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation.
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A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation.

机译：长期暴露于低剂量伽玛射线引起的白血病风险的荟萃分析。

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CONTEXT: More than 400,000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure. OBJECTIVE: We conducted a meta-analysis examining the relationship between protracted low-dose ionising radiation exposure and leukaemia. DATA SOURCES: Reviews by the National Academies and United Nations provided a summary of informative studies published before 2005. PubMed and Embase databases were searched for additional occupational and environmental studies published between 2005 and 2009. STUDY SELECTION: We selected 23 studies that: (1) examined the association between protracted exposures to ionising radiation and leukaemia excluding chronic lymphocytic subtype; (2) were a cohort or nested case-control design without major bias; (3) reported quantitative estimates of exposure; and (4) conducted exposure-response analyses using relative or excess RR per unit exposure. METHODS: Studies were further screened to reduce information overlap. Random effects models were developed to summarise between-study variance and obtain an aggregate estimate of the excess RR at 100 mGy. Publication bias was assessed by trim and fill and Rosenthal's file drawer methods. RESULTS: We found an ERR at 100 mGy of 0.19 (95% CI 0.07 to 0.32) by modelling results from 10 studies and adjusting for publication bias. Between-study variance was not evident (p=0.99). CONCLUSIONS: Protracted exposure to low-dose gamma radiation is significantly associated with leukaemia. Our estimate agreed well with the leukaemia risk observed among exposed adults in the Life Span Study (LSS) of atomic bomb survivors, providing increased confidence in the current understanding of leukaemia risk from ionising radiation. However, unlike the estimates obtained from the LSS, our model provides a precise, quantitative summary of the direct estimates of excess risk from studies of protracted radiation exposures.
机译：背景：每年有超过40万名工人接受可测量的放射剂量，并可能增加放射诱发的白血病的风险。尚不清楚长期，低剂量暴露是否会增加白血病的风险。目的：我们进行了荟萃分析，研究了长期低剂量电离辐射暴露与白血病之间的关系。数据来源：美国国家科学院和联合国的评论提供了2005年之前发表的信息研究的摘要。搜索PubMed和Embase数据库以查找2005年至2009年之间发表的其他职业和环境研究。研究选择：我们选择了23项研究：（1 ）研究了长期暴露于电离辐射与白血病（不包括慢性淋巴细胞亚型）之间的关系; （2）是队列研究或嵌套病例对照设计，没有重大偏见; （3）报告了暴露的定量估计; （4）使用每单位暴露量的相对或过量RR进行暴露量响应分析。方法：进一步筛选研究以减少信息重叠。开发了随机效应模型以总结研究之间的方差，并获得100 mGy时过量RR的总和。通过裁切和填充以及Rosenthal的文件抽屉方法评估出版偏向。结果：我们通过对10项研究的结果进行建模并对发布偏倚进行了调整，发现100 mGy时的ERR为0.19（95％CI为0.07至0.32）。研究之间的差异不明显（p = 0.99）。结论：长时间暴露于低剂量伽马射线辐射与白血病显着相关。我们的估计与原子弹幸存者的生命跨度研究（LSS）中在暴露的成年人中观察到的白血病风险高度吻合，从而使人们对当前对电离辐射导致的白血病风险的认识有了更大的信心。但是，与从LSS获得的估计不同，我们的模型提供了对长期辐射暴露进行研究的过度风险直接估计的精确，定量摘要。

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