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首页> 外文期刊>Occupational and environmental medicine >Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals
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Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals

机译：气温对潜在易感人群凝血和炎症的血液标志物的短期影响

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Objectives: Changes in air temperature are associated with an increase in cardiovascular events, but the role of procoagulant and proinflammatory blood markers is still poorly understood. The authors investigated the association between air temperature and fibrinogen, plasminogen activator inhibitor type 1, interleukin-6 and high-sensitivity C reactive protein in two potentially susceptible groups. Methods: This prospective panel study was conducted between March 2007 and December 2008 in Augsburg, Germany. The study population comprised 187 participants with type 2 diabetes mellitus or impaired glucose tolerance and 87 participants with genetic polymorphisms on the detoxification and inflammation pathways. Overall, 1766 repeated blood measurements were collected. Hourly meteorology data were available from a central measurement site. The association between temperature and blood markers was analysed with additive mixed models. Results: For type 2 diabetes mellitus and impaired glucose tolerance participants, the authors observed immediate, lagged and cumulative increases in fibrinogen (range of percentage changes in geometric mean: 0.6%-0.8%) and plasminogen activator inhibitor type 1 (6.0%-10.1%) in association with a 58C temperature decrement. Participants with a body mass index above 30 kg/m 2 as well as females showed particularly strong fibrinogen effects. In participants with the special genetic background, 58C decreases in the 5-day average of temperature led to a change of 8.0% (95% CI 0.5% to 16.2%) in interleukin-6 and of -8.4% (95% CI -15.8% to -0.3%) in high-sensitivity C reactive protein, the latter driven by physically active individuals. Conclusions The authors observed different temperature effects on blood markers in two potentially susceptible groups probably indicating varying underlying biological mechanisms. This study results might provide a link between temperature and cardiovascular events.
机译：目的：气温的变化与心血管事件的增加有关，但促凝剂和促炎性血液标志物的作用仍知之甚少。作者研究了两个潜在易感人群中气温与纤维蛋白原，纤溶酶原激活物抑制剂1型，白介素6和高敏C反应蛋白之间的关系。方法：这项前瞻性小组研究于2007年3月至2008年12月在德国奥格斯堡进行。研究人群包括187名2型糖尿病或糖耐量减退的参与者和87位在解毒和炎症途径上具有遗传多态性的参与者。总体上，收集了1766次重复的血液测量结果。每小时的气象数据可从中央测量站点获得。用加性混合模型分析温度和血液标志物之间的关联。结果：对于2型糖尿病和糖耐量减退的参与者，作者观察到纤维蛋白原（几何平均值的百分比变化范围：0.6％-0.8％）和1型纤溶酶原激活物抑制剂（6.0％-10.1）立即，滞后和累积增加％）与58°C的温度降低有关。体重指数高于30 kg / m 2的参与者以及女性表现出特别强烈的纤维蛋白原作用。具有特殊遗传背景的参与者在5天平均温度下降58C时导致白介素6的变化为8.0％（95％CI为0.5％至16.2％），而-8.4％（95％CI -15.8为） ％至-0.3％）的高敏感性C反应蛋白，后者由身体活跃的个体驱动。结论作者在两个潜在易感人群中观察到温度对血液标志物的不同影响，可能表明其潜在的生物学机制不同。这项研究结果可能提供温度和心血管事件之间的联系。

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