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首页> 外文期刊>Occupational and environmental medicine >Chronic rhinitis in workers at risk of reactive airways dysfunction syndrome due to exposure to chlorine.
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Chronic rhinitis in workers at risk of reactive airways dysfunction syndrome due to exposure to chlorine.

机译：工人因接触氯气而患有慢性鼻炎，有发生反应性气道功能障碍综合症的危险。

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BACKGROUND: To assess the frequency of chronic upper airways symptoms and to relate the presence of these symptoms to accidental exposure to chlorine and changes in lower airways symptoms, airway function, and bronchial responsiveness in a cohort of workers at risk of sporadic occupational exposure to high concentrations of chlorine. METHODS: Data were collected on symptom assessment, spirometry, and methacholine challenge tests from 211 workers seen twice at a 2 year interval (1992-4). RESULTS: The proportion of workers reporting chronic rhinitis was 46.9% in 1992 and 42.2% in 1994. Chronic rhinitis reported in 1994 was significantly associated with acute exposure to chlorine (self reports, p = 0.02; first aid reports, p = 0.001). In a multivariate logistic regression analysis the presence of reported accidents at the first aid unit (one accident, odds ratio (OR) 3.1, 95% confidence interval (95% CI) 1.3 to 7.5; two or more accidents, OR 6.2, 1.1 to 35.8) and of personal atopy (OR 5.5, 2.2 to 10.8) were significant predictors of chronic rhinitis in 1994. Chronic lower airways symptoms were more frequent in 1994 among workers reporting chronic rhinitis on both assessments than in others (p = 0.03) and changes in bronchial responsiveness were more pronounced in those with persistent rhinitis (p = 0.09). CONCLUSIONS: These results suggest that persistent nasal symptoms in workers at risk of reactive airways dysfunction syndrome could be a useful marker of lower respiratory tract abnormalities.
机译：背景：为了评估慢性上呼吸道症状的发生频率，并将这些症状的存在与意外暴露于氯气中以及下肢气道症状的改变，气道功能和支气管反应性的变化联系起来，该队列中的工人有零星的职业性接触高风险氯的浓度。方法：收集了211名工作人员的症状评估，肺活量测定法和乙酰甲胆碱激发试验的数据，每隔2年两次（1992-4）。结果：报告慢性鼻炎的工人比例在1992年为46.9％，在1994年为42.2％。1994年报告的慢性鼻炎与急性暴露于氯有显着相关（自我报告，p = 0.02;急救报告，p = 0.001）。在多变量logistic回归分析中，报告的急救单位发生事故（一次事故，比值比（OR）3.1、95％置信区间（95％CI）1.3至7.5;两次或更多事故，OR 6.2、1.1至35.8）和个人特应性疾病（OR 5.5，2.2至10.8）是1994年慢性鼻炎的重要预测指标。1994年，两项评估均报告为慢性鼻炎的工人的慢性下呼吸道症状在其他评估中更为常见（p = 0.03）和变化。在患有持续性鼻炎的患者中，支气管反应性的升高更为明显（p = 0.09）。结论：这些结果表明，在具有反应性气道功能障碍综合征风险的工人中持续出现的鼻部症状可能是下呼吸道异常的有用标志。

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