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首页> 外文期刊>Occupational and environmental medicine >Haematological and spermatotoxic effects of ethylene glycol monomethyl ether in copper clad laminate factories.
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Haematological and spermatotoxic effects of ethylene glycol monomethyl ether in copper clad laminate factories.

机译：乙二醇单甲醚在覆铜箔层压板工厂中的血液学和精子毒性作用。

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OBJECTIVES: To investigate the effects of ethylene glycol monomethyl ether (EGME) on haematology and reproduction in exposed workers. METHODS: 53 Impregnation workers from two factories that make copper clad laminate with EGME as a solvent were recruited as the exposed group. Another group of 121 lamination workers with indirect exposure to EGME was recruited as the control group. Environmental monitoring of concentrations of EGME in air and biological monitoring of urinary methoxyacetic acid (MAA) concentrations were performed. Venous blood was collected for routine and biochemical analyses. Semen was collected from 14 workers exposed to EGME for sperm analysis and was compared with 13 control workers. RESULTS: Results of haematological examination showed that the haemoglobin, packed cell volume, and red blood cell count in the male workers exposed to EGME were significantly lower than in the controls. The frequency of anaemia in the exposed group (26.1%) was significantly higher than in the control group (3.2%). However, no differences were found between the female workers exposed and not exposed to EGME. After adjustment for sex, body mass index, and duration of employment, red blood cell count was significantly negatively associated with air concentrations of EGME, and haemoglobin, packed cell volume, and red blood cell count were significantly negatively associated with urinary concentrations of MAA. The pH of semen in the exposed workers was significantly lower than in the control workers, but there were no significant differences in the sperm count or sperm morphology between the exposed and control groups. CONCLUSION: It can be concluded that EGME is a haematological toxin, which leads to anaemia in the exposed workers. However, the data from this study did not support the theory of a spermatotoxic effect of EGME.
机译：目的：研究乙二醇单甲醚（EGME）对裸露工人血液学和生殖的影响。方法：招募了两家工厂的53名浸渍工人，他们以EGME作为溶剂制造覆铜箔层压板作为暴露组。招募了另一组121名间接接触EGME的层压工人作为对照组。进行了空气中EGME浓度的环境监测和尿中甲氧乙酸（MAA）浓度的生物监测。收集静脉血用于常规和生化分析。从暴露于EGME的14名工人收集精液进行精子分析，并将其与13名对照工人进行比较。结果：血液学检查结果显示，暴露于EGME的男性工人的血红蛋白，堆积细胞体积和红细胞计数显着低于对照组。暴露组的贫血发生率（26.1％）显着高于对照组（3.2％）。但是，未接触和未接触EGME的女工之间没有发现差异。在对性别，体重指数和就业时间进行调整后，红细胞计数与空气中EGME浓度显着负相关，而血红蛋白，堆积细胞体积和红细胞计数与MAA尿液浓度显着负相关。暴露工人的精液pH值明显低于对照工人，但暴露组和对照组之间精子数量或精子形态没有显着差异。结论：可以得出结论，EGME是一种血液毒素，可导致暴露工人贫血。但是，这项研究的数据不支持EGME的精子毒性作用理论。

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