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In dust in primary schools and respiratory health in schoolchildren across Europe

机译:欧洲各地小学的灰尘和学童的呼吸系统健康

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Methods Primary schools in Spain, the Netherlands and Finland were selected on the basis of the observed presence (n=15) or absence (n=10) of moisture, dampness and/or mould. Settled dust was repeatedly sampled in 232 classrooms and levels of 14 different microbial markers and groups of microbes were determined. Parental reports of respiratory symptoms were available from 3843 children aged 6-12 years, of whom 2736 provided acceptable forced spirometry testing. Country-specific associations between exposure and respiratory health were evaluated by multilevel mixed-effects logistic and linear regression models and combined using random-effects meta-analysis.Results The prevalence of respiratory symptoms was higher in moisture damaged schools, being more pronounced in Finnish pupils. Effects on lung function were not apparent. Levels of microbial markers were generally higher in moisture damaged schools, varied by season and were lower in Finnish schools. Wheeze tended to be inversely associated with microbial levels. All other respiratory symptoms were not consistently associated with microbial marker levels.Conclusions Health effects of moisture and microbial exposures may vary between countries, but this requires further study.Background Respiratory health effects of damp housing are well recognised, but less is known about the effect of dampness and water damage in schools. The HITEA study previously reported a higher prevalence of respiratory symptoms in pupils from moisture damaged schools, but the role of specific microbial exposures remained unclear.Objectives To study associations between school dampness, levels of fungal and bacterial markers, respiratory symptoms and lung function in children.
机译:方法根据观察到的水分,湿气和/或霉菌的存在(n = 15)或不存在(n = 10)选择西班牙,荷兰和芬兰的小学。在232个教室中反复采样了沉降的灰尘,并确定了14种不同的微生物标记物和微生物组的水平。父母报告了3843名6-12岁儿童的呼吸道症状,其中2736名提供了可接受的强制肺活量测试。通过多层次混合效应逻辑和线性回归模型并结合随机效应荟萃分析,评估了暴露与呼吸健康之间的国家特定关联。结果在受湿气损害的学校中,呼吸系统症状的患病率较高,在芬兰小学生中更为明显。对肺功能的影响尚不明显。在受湿气损坏的学校中,微生物标记物的水平通常较高,随季节而变化,而在芬兰的学校中则较低。喘息倾向于与微生物水平成反比。其他所有呼吸道症状均未与微生物标志物水平保持一致。结论各国之间的水分和微生物暴露对健康的影响可能有所不同,但这需要进一步研究背景潮湿房屋对呼吸道健康的影响众所周知,但对其影响知之甚少和潮湿对学校的破坏。 HITEA的研究先前报告说,受湿气损害的学校的学生呼吸道症状患病率较高,但具体微生物暴露的作用仍不清楚。目的研究学校潮湿,儿童真菌和细菌标志物水平,呼吸道症状和肺功能之间的关系。

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