Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes.

Alonso R; Mazzeo C; Rodriguez MC; Marsh M; Fraile Ramos A; Calvo V; Avila Flores A; Merida I; Izquierdo M

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Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes.

机译：二酰基甘油激酶α调节成熟的多囊小体的形成和极化，该多囊小体参与T淋巴细胞中含有Fas配体的囊泡的分泌。

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Multivesicular bodies (MVBs) are endocytic compartments that contain intraluminal vesicles formed by inward budding from the limiting membrane of endosomes. In T lymphocytes, these vesicles contain pro-apoptotic Fas ligand (FasL), which may be secreted as 'lethal exosomes' upon fusion of MVBs with the plasma membrane. Diacylglycerol kinase alpha (DGKalpha) regulate the secretion of exosomes, but it is unclear how this control is mediated. T-lymphocyte activation increases the number of MVBs that contain FasL. DGKalpha is recruited to MVBs and to exosomes in which it has a double function. DGKalpha kinase activity exerts a negative role in the formation of mature MVBs, as we demonstrate by the use of an inhibitor. Downmodulation of DGKalpha protein resulted in inhibition of both the polarisation of MVBs towards immune synapse and exosome secretion. The subcellular location of DGKalpha together with its complex role in the formation and polarised traffic of MVBs support the notion that DGKalpha is a key regulator of the polarised secretion of exosomes.

机译：多囊泡体（MVB）是内吞的隔室，其中包含腔内囊泡，囊泡是通过从内体的限制膜向内发芽形成的。在T淋巴细胞中，这些囊泡含有促凋亡的Fas配体（FasL），当MVB与质膜融合时，它可能以“致命外泌体”的形式分泌。二酰基甘油激酶α（DGKalpha）调节外泌体的分泌，但尚不清楚该调控是如何介导的。 T淋巴细胞激活会增加含有FasL的MVB的数量。 DGKalpha被募集到MVB和具有双重功能的外泌体中。 DGKalpha激酶活性在成熟MVB的形成中起着负面作用，正如我们通过使用抑制剂所证明的那样。 DGKalpha蛋白的下调导致抑制MVB向免疫突触和外来体分泌的极化。 DGKalpha的亚细胞位置及其在MVB的形成和极化运输中的复杂作用支持了DGKalpha是外泌体极化分泌的关键调节因子的观点。

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《Cell death and differentiation》 |2011年第7期|共13页
作者
Alonso R; Mazzeo C; Rodriguez MC; Marsh M; Fraile Ramos A; Calvo V; Avila Flores A; Merida I; Izquierdo M;
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正文语种 eng
中图分类细胞生物学;
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1. Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes. [J] . Alonso R, Mazzeo C, Rodriguez MC, Cell death and differentiation . 2011,第7期

机译：二酰基甘油激酶α调节成熟的多囊小体的形成和极化，该多囊小体参与T淋巴细胞中含有Fas配体的囊泡的分泌。
2. A new role of diacylglycerol kinase a on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes [J] . Roberto Alonso, Carla Mazzeo, Isabel Merida, Biochimie . 2007,第2期

机译：二酰基甘油激酶a在活化诱导的T淋巴细胞死亡过程中对带有Fas配体的致死性外泌体分泌的新作用
3. A new role of diacylglycerol kinase α on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes [J] . Roberto Alonso, Carla Mazzeo, Isabel Merida, Biochimie . 2007,第2期

机译：二酰基甘油激酶α在活化诱导的T淋巴细胞死亡过程中对Fas配体致死性外泌体分泌的新作用
4. PERK EIF2alpha kinase regulates cell proliferation, insulin synthesis and secretion in pancreatic beta cells. [D] . Wang, Rong. 2014

机译：PERK EIF2alpha激酶调节胰腺β细胞中的细胞增殖，胰岛素合成和分泌。
5. Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes [O] . R Alonso, C Mazzeo, M C Rodriguez, 2011

机译：二酰基甘油激酶α调节成熟的多囊小体的形成和极化该多囊小体参与T淋巴细胞中含有Fas配体的囊泡的分泌
6. Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes [O] . Alonso, Roberto, Mazzeo, C., Rodríguez, María del Carmen, 2013

机译：二酰基甘油激酶α调节成熟的多囊小体的形成和极化，该多囊小体参与T淋巴细胞中含有Fas配体的囊泡的分泌

Diacylglycerol kinase alpha regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes.

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