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Effects of Meloxicam on oxidative deterioration due to exercise in horses

机译：美洛昔康对马匹运动引起的氧化退化的影响

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In this study, the effects of meloxicam, a not steroidal anti-inflammatory drug (NSAID), on the oxidative status were evaluated in exercised horses. Sixteen healthy horses were normally trained for 2 hours and immediately after, the half of them wereintravenously injected by a single dose of meloxicam (0.6 mg/kg) whereas the 8 others were treated with NaCl 0.9% in the same way. Physical parameters (rectal temperature, heart and respiratory frequencies) and eventual inflammatory clinical signs, venous blood gas, serum biochemical markers such as glucose and protein concentrations, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activities and plasma malondialdehyde (MDA) concentrations and superoxidedismutase (SOD) activities were investigated before (-2 hours), immediately after the exercise and 1, 3, 5 and 7 hours after. Immediately after the exercise which has induced a transient CO_2 accumulation coupled to a high and prolonged O_2 consumption,the physical parameters, the serum AST activities and the plasma MDA concentrations significantly increased whereas the plasma SOD activities were greatly reduced. Compared to the control horses, the meloxicam treated horses exhibited a more rapid clinical recovery associated to a more efficient CO_2 elimination and tissue O_2 delivery, less prolonged AST variations and marked increases in the SOD activities in the post-exercise period. These results demonstrate that a strenuous exercise induced an oxidative stress in horses and that meloxicam affects the oxidative status by strengthening the SOD activity.
机译：在这项研究中，在运动马中评估了美洛昔康（一种非甾体类抗炎药，NSAID）对氧化状态的影响。通常对16匹健康的马进行2小时的训练，之后立即对它们进行半静脉注射单剂量美洛昔康（0.6 mg / kg）的静脉注射，而其他8匹马则以0.9％的NaCl进行相同的治疗。物理参数（直肠温度，心脏和呼吸频率）以及最终的炎症性临床体征，静脉血气，血清生化标记（例如葡萄糖和蛋白质浓度），天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT）和乳酸脱氢酶（LDH）的活性以及在运动前（-2小时），运动后立即以及运动后1、3、5和7小时对血浆丙二醛（MDA）浓度和超氧化物歧化酶（SOD）活性进行了研究。运动引起短暂的CO_2累积并伴随着大量的O_2消耗后，运动后即刻，身体参数，血清AST活性和血浆MDA浓度显着增加，而血浆SOD活性则大大降低。与对照马相比，经美洛昔康治疗的马表现出更快的临床恢复，与运动后更有效的CO_2消除和组织O_2输送，更短的AST变异以及SOD活性显着增加有关。这些结果表明，剧烈运动会引起马的氧化应激，而美洛昔康可通过增强SOD活性来影响其氧化状态。

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