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首页> 外文期刊>Revue de Medecine Veterinaire >Spontaneous bilateral epistaxis associated with the administration of phenylbutazone in a horse.
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Spontaneous bilateral epistaxis associated with the administration of phenylbutazone in a horse.

机译：与马中服用苯丁氮酮有关的自发性双侧鼻出血。

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A 15-year-old male Selle Francais horse was presented because of some episodes of spontaneous mild bilateral epistaxis lasting for 7 days. No history of recent trauma was reported, and decrease in exercise performance and respiratory symptoms both at rest and during exercise was not observed. Nasal discharge between episodes of epistaxis was neither seen. The horse had received phenylbutazone at therapeutic doses for three weeks in order to be treated for chronic lameness (osteoarthritis). Physical examination was quite normal but blood analysis revealed a mild anaemia, hypoproteinemia, hypoalbuminemia and increased prothrombin time and activated partial thromboplastin time. Endoscopy of the respiratory airways evidenced ulcers in the nasal cavity and in the pharynx. Clinical signs disappeared after removing phenylbutazone therapy and epistaxis was not longer observed. This case indicates that although gastrointestinal ulceration and renal papillary necrosis are the most common clinical alterations due to the toxicity of the non-steroid anti-inflammatory drugs in horses, other symptoms associated with coagulopathies such as ulcers in the respiratory airways might appear.
机译：出现了15岁的雄性Selle Francais马，原因是自发性轻度双侧鼻epi持续了7天。没有近期创伤史的报道，在休息和运动期间均未观察到运动表现和呼吸道症状的降低。没有见到鼻epi发作之间的鼻分泌物。这匹马接受了三周治疗剂量的苯丁氮卓治疗，以治疗慢性la行症（骨关节炎）。体格检查相当正常，但血液分析显示有轻度贫血，低蛋白血症，低白蛋白血症，凝血酶原时间增加和部分凝血活酶时间活化。呼吸道的内窥镜检查显示鼻腔和咽部有溃疡。取消苯丁氮酮治疗后临床症状消失，不再观察到鼻epi。该病例表明，尽管由于非甾体类抗炎药对马的毒性，胃肠道溃疡和肾乳头坏死是最常见的临床改变，但可能会出现其他与凝血病相关的症状，例如呼吸道溃疡。

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