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首页> 外文期刊>Revue de Medecine Veterinaire >Influence of high dietary nitrate intake and sulphur supplementation on oxidant / antioxidant balance and on some haematological parameters in Angora goats
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Influence of high dietary nitrate intake and sulphur supplementation on oxidant / antioxidant balance and on some haematological parameters in Angora goats

机译：饮食中硝酸盐摄入量高和补充硫对安哥拉山羊氧化/抗氧化剂平衡及某些血液学参数的影响

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摘要

This study was conducted in order to determine the potential effects of a high nitrate food intake, known to cause chronic poisoning, on the oxidant / antioxidant balance and on some haematological parameters in goats and the putative protecting effects of a dietary sulphur supplementation. Eighteen male adult angora goats were divided into three equal groups: in the first group, goats were fed with a nitrate enriched diet (1500 ppm per day) and in the second group, animals received diets enriched with nitrate (1500 ppm) and sodium sulphate (1.8%) for 60 days whereas controls were fed with a standard diet. At the end of the trial, haematological parameters (red blood cell and white blood cell counts, haemoglobinemia and haematocrit), plasma malon-dialdehyde (MDA), nitrateitrite, glutathione (GSH) concentrations, total antioxidant activity (AOA), glutathione peroxidase (GPx) activity and erythrocyte catalase (CAT) activity were determined in all animals. While haematological parameters were not altered among groups, significant increases in the MDA concentrations and GPx activities were coupled to marked decreases in the antioxidant systems (GSH, CAT and AO A) in goats chronically exposed to nitrate compared to controls and intermediate values except for GPx which were strongly elevated were recorded in chronically nitrate-intoxicated ruminants supplemented with sulphur. These results show that an oxidative stress occurred in chronic nitrate poisoning that can be markedly alleviated with dietarysulphur supplementation in goats.
机译：进行这项研究的目的是确定摄入高硝酸盐食物（可能会引起慢性中毒）对山羊中的氧化剂/抗氧化剂平衡和某些血液学参数的潜在影响，以及确定膳食中补充硫的潜在保护作用。将18只成年安哥拉山羊分成三等份：在第一组中，给山羊饲喂富含硝酸盐的饮食（每天1500 ppm），在第二组中，动物接受富含硝酸盐（1500 ppm）和硫酸钠的饮食（1.8％）持续60天，而对照组则接受标准饮食。在试验结束时，血液学参数（红细胞和白细胞计数，血红蛋白血症和血细胞比容），血浆丙二醛（MDA），硝酸盐/亚硝酸盐，谷胱甘肽（GSH）浓度，总抗氧化活性（AOA），谷胱甘肽测定了所有动物的过氧化物酶（GPx）活性和红细胞过氧化氢酶（CAT）活性。虽然各组之间的血液学参数没有改变，但与对照组相比，MDX浓度和GPx活性的显着增加与长期暴露于硝酸盐的山羊的抗氧化系统（GSH，CAT和AO A）显着降低相比，GPx除外在长期补充硝酸盐的硝酸盐中毒反刍动物中记录到强烈升高。这些结果表明，在慢性硝酸盐中毒中发生了氧化应激，可以通过补充山羊中的饮食硫来显着缓解氧化应激。

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