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首页> 外文期刊>Cellular Signalling >Involvement of extracellular Ca2+ influx through voltage-independent Ca2+ channels in endothelin-1 function
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Involvement of extracellular Ca2+ influx through voltage-independent Ca2+ channels in endothelin-1 function

机译：通过电压独立的Ca2 +通道参与细胞外Ca2 +内流在内皮素1功能中的作用

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摘要

This article reviews the types and roles of voltage-independent Ca2+ channels involved in the endothelin-1 (ET-1)-induced functional responses such as vascular contraction, cell proliferation, and intracellular Ca2+-dependent signaling pathways and discusses the molecular mechanisms for the activation of voltage-independent Ca2+ channels by ET-1. ET-1 activates some types of voltage-independent Ca2+ channels, such as Ca2+-penneable nonselective cation channels (NSCCs) and store-operated Ca2+ channels (SOCC). Extracellular Ca2+ influx through these voltage-independent Ca2+ channels plays essential roles in ET-1-induced vascular contraction, cell proliferation, activation of epidermal growth factor receptor tyrosine kinase, regulation of proline-rich tyrosine kinase, and release of arachidonic acid. The experiments using various constructs of endothelin receptors reveal the importance of G(q) and G(12) families in activation of these Ca2+ channels by ET-1. These findings provide a potential therapeutic mechanism of a functional interrelationship between G(q)/G(12) proteins and voltage-independent Ca2+ channels in the pathophysiology of ET-1, such as in chronic heart failure, hypertension, and cerebral vasospasm. (c) 2005 Elsevier Inc. All rights reserved.
机译：本文综述了内皮素-1（ET-1）诱导的功能反应（如血管收缩，细胞增殖和细胞内Ca2 +依赖性信号传导途径）中与电压无关的Ca2 +通道的类型和作用，并探讨了这种机制的分子机制。 ET-1激活不依赖电压的Ca2 +通道。 ET-1激活某些类型的电压无关的Ca2 +通道，例如可透过Ca2 +的非选择性阳离子通道（NSCC）和存储操作的Ca2 +通道（SOCC）。通过这些电压独立的Ca2 +通道流入的细胞外Ca2 +在ET-1诱导的血管收缩，细胞增殖，表皮生长因子受体酪氨酸激酶的活化，富含脯氨酸的酪氨酸激酶的调节以及花生四烯酸的释放中起着重要作用。使用各种内皮素受体构建物的实验揭示了ET-1激活这些Ca2 +通道对G（q）和G（12）家族的重要性。这些发现为ET-1的病理生理学（例如在慢性心力衰竭，高血压和脑血管痉挛中）的G（q）/ G（12）蛋白质与电压无关的Ca2 +通道之间的功能性相互关系提供了潜在的治疗机制。 （c）2005 Elsevier Inc.保留所有权利。

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