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Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective

机译:支架介导的MAPK信号传导和细胞骨架动力学的调节:一个角度

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摘要

Cell migration is critical for many physiological processes and is often misregulated in developmental disorders and pathological conditions including cancer and neurodegeneration. MAPK signaling and the Rho family of proteins are known regulators of cell migration that exert their influence on cellular cytoskeleton during cell adhesion and migration. Here we review data supporting the view that localized ERK signaling mediated through recently identified scaffold proteins may regulate cell migration. (c) 2007 Elsevier Inc. All rights reserved.
机译:细胞迁移对于许多生理过程至关重要,并且经常在发育障碍和病理状况(包括癌症和神经变性)中被错误调节。 MAPK信号传导和Rho蛋白家族是已知的细胞迁移调节剂,在细胞粘附和迁移过程中会影响细胞骨架。在这里,我们审查数据支持的观点,即通过最近发现的支架蛋白介导的局部ERK信号传导可能调节细胞迁移。 (c)2007 Elsevier Inc.保留所有权利。

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