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首页> 外文期刊>Biomaterials >Silicon substitution in the calcium phosphate bioceramics.
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Silicon substitution in the calcium phosphate bioceramics.

机译：磷酸钙生物陶瓷中的硅取代。

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摘要

Silicon (Si) substitution in the crystal structures of calcium phosphate (CaP) ceramics such as hydroxyapatite (HA) and tricalcium phosphate (TCP) generates materials with superior biological performance to stoichiometric counterparts. Si, an essential trace element required for healthy bone and connective tissues, influences the biological activity of CaP materials by modifying material properties and by direct effects on the physiological processes in skeletal tissue. The synthesis of Si substituted HA (Si-HA), Si substituted alpha-TCP (Si-alpha-TCP), and multiphase systems are reviewed. The biological performance of these Si substituted CaP materials in comparison to stoichiometric counterparts is discussed. Si substitution promotes biological activity by the transformation of the material surface to a biologically equivalent apatite by increasing the solubility of the material, by generating a more electronegative surface and by creating a finer microstructure. When Si is included in the TCP structure, recrystallization to a carbonated HA is mediated by serum proteins and osteoblast-like cells. Release of Si complexes to the extracellular media and the presence of Si at the material surface may induce additional dose-dependent stimulatory effects on cells of the bone and cartilage tissue systems.
机译：磷酸钙（CaP）陶瓷（例如羟基磷灰石（HA）和磷酸三钙（TCP））的晶体结构中的硅（Si）取代产生的材料具有比化学计量对应物更好的生物学性能。硅是健康骨骼和结缔组织所需的必需微量元素，它通过改变材料的性质以及对骨骼组织中生理过程的直接影响，影响CaP材料的生物活性。综述了Si取代的HA（Si-HA），Si取代的α-TCP（Si-alpha-TCP）和多相系统的合成。讨论了与化学计量对应物相比，这些Si取代的CaP材料的生物学性能。硅取代通过增加材料的溶解度，产生更大的负电性表面并产生更精细的微观结构，将材料表面转变为生物等效的磷灰石来促进生物活性。当TCP结构中包含Si时，血清蛋白和成骨细胞样细胞介导重结晶为碳酸HA。 Si复合物释放到细胞外介质中，以及在材料表面存在Si可能会对骨骼和软骨组织系统的细胞产生额外的剂量依赖性刺激作用。

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