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首页> 外文期刊>Cellular Signalling >The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis
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The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis

机译：细胞粘附分子在大肠癌进展和肝转移发展中的作用

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Cell adhesion molecules (CAMs) play a significant role in the metastatic potential of colorectal cancer and thus mediate the prognosis of this common malignancy. The downregulation of cadherins and catenins facilitates tumour cell detachment from the primary site, while the expression of selectins, integrins and members of the immunoglobulin superfamily may support neoplastic progression, intravasation and malignant cell attachment to foreign tissue, leading to the development of metastases. The liver is the main host organ of colorectal metastatic lesions. The process of hepatic invasion originates in the sinusoids, where non-parenchymal cells interact with metastasising ones. through the expression of numerous CAMs, following complex molecular pathways. Concurrently, the selective expression of cell adhesion molecules on different organs and endothelia, in conjunction with the presence of dissimilar adhesion ligands on various colorectal cancer cell lines, suggest that CAMs may also mediate the selection of the host organ, for the development of distant colorectal metastases.
机译：细胞粘附分子（CAMs）在结直肠癌的转移潜力中起着重要作用，因此介导了这种常见恶性肿瘤的预后。钙黏着蛋白和连环蛋白的下调促进肿瘤细胞从原发部位脱离，而选择蛋白，整联蛋白和免疫球蛋白超家族成员的表达可能支持肿瘤的进展，血管内侵入和恶性细胞附着于异物组织，从而导致转移的发展。肝脏是结直肠转移性病变的主要宿主器官。肝的侵袭过程起源于正弦曲线，其中非实质细胞与转移细胞相互作用。通过遵循复杂的分子途径表达大量CAM。同时，细胞黏附分子在不同器官和内皮上的选择性表达，以及在各种结直肠癌细胞系上存在不同的黏附配体，提示CAMs也可能介导宿主器官的选择，从而发展远处的结直肠转移。

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