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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Expression and clinical significance of the G1-S modulators in intrahepatic cholangiocellular carcinoma.
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Expression and clinical significance of the G1-S modulators in intrahepatic cholangiocellular carcinoma.

机译：G1-S调节剂在肝内胆管细胞癌中的表达及其临床意义。

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OBJECTIVE: To elucidate the clinical roles of G1-S modulators in cholangiocellular carcinoma (CCC). METHODS: We performed immunohistochemistry using antibodies against the retinoblastoma gene product (pRb), p16, p21, p27, p53 and cyclin D1 for 41 cases of CCC as well as normal bile ducts. RESULTS: The p27 labeling index (LI) was significantly higher in cases without lymph node metastasis than in normal bile ducts, but it decreased greatly in cases with lymph node metastasis. It was inversely related to the Ki-67 LI. The p16 LI also showed a relationship with lymph node metastasis, but not with the Ki-67 LI. The p21 LI was even higher in poorly differentiated cases and showed a direct relationship with the Ki-67 LI, although it is a negative regulator of the cell cycle. pRb expression did not correlate with any clinicopathological features. Cyclin D1 overexpression was more frequently observed in cases with poor or moderate differentiation and with lymph node metastasis. Cyclin D1 overexpression and aberrant p53 expression showed direct relationships with the Ki-67 LI. CONCLUSIONS: These results suggest that in CCC: (1) p27 expression reflects the biological character of the carcinoma and may regulate its progression; (2) cyclin D1 plays a crucial role in cell cycle progression, and (3) aberrant p53 expression has some effect on CCC cell proliferating activity. Copyright 2001 S. Karger AG, Basel
机译：目的：阐明G1-S调节剂在胆管细胞癌（CCC）中的临床作用。方法：我们使用针对视网膜母细胞瘤基因产物（pRb），p16，p21，p27，p53和cyclin D1的抗体对41例CCC和正常胆管进行了免疫组织化学。结果：无淋巴结转移者p27标记指数（LI）明显高于正常胆管，但有淋巴结转移者p27标记指数（LI）明显降低。它与Ki-67 LI成反比。 p16 LI也显示与淋巴结转移有关，但与Ki-67 LI无关。尽管p21 LI是细胞周期的负调节剂，但在分化较差的病例中p21 LI甚至更高，并且与Ki-67 LI表现出直接的关系。 pRb表达与任何临床病理特征均不相关。在分化差或中度分化并伴淋巴结转移的病例中，细胞周期蛋白D1过表达更为常见。细胞周期蛋白D1过表达和p53异常表达与Ki-67 LI直接相关。结论：这些结果表明，在CCC中：（1）p27表达反映了癌的生物学特性，并可能调节其进展; （2）细胞周期蛋白D1在细胞周期进程中起着至关重要的作用，（3）p53异常表达对CCC细胞的增殖活性有一定影响。版权所有2001 S. Karger AG，巴塞尔

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