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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Anticarcinogenic effects of isoflavones may be mediated by genistein in mouse mammary tumor virus-induced breast cancer.
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Anticarcinogenic effects of isoflavones may be mediated by genistein in mouse mammary tumor virus-induced breast cancer.

机译：异黄酮的抗癌作用可能是由染料木黄酮在小鼠乳腺肿瘤病毒诱发的乳腺癌中介导的。

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摘要

Isoflavones are known to exert anticancer effects. These effects were examined using two isoflavones, biochanin A and daidzein, in a mouse mammary tumor virus (MMTV)-induced spontaneous breast cancer model. Emphasis was placed on isoflavone metabolism by the intestinal microflora and changes in estrogen levels. Germ-free (Gf) mice and their conventionalized (Cv) counterparts were assigned to three diet groups: (1) control diet, (2) biochanin A and (3) daidzein. In all groups, urine was collected from virgin female mice to analyze isoflavone metabolism by high performance liquid chromatography. These studies revealed changes of biochanin A into genistein, and of daidzein into equol, which were accelerated in the Cv animals. However, the Gf mice could not transform biochanin A into genistein, or daidzein into equol. Estrogen levels in the control and daidzein diet groups were lower in the Gf mice than in the Cv mice. The biochanin A group showed no differences in estrogen levels between the Cv and Gf animals. Four-week-old male and female animals were paired in the Gf and Cv groups. The female animals delivered and lactated repeatedly and were observed for the development of mammary cancer by palpation, twice weekly, until 15 months of age. The Cv mice showed a significantly lower incidence of breast cancer in the biochanin A diet group than in the control or daidzein groups (p < 0.05). These results suggest that the anticarcinogenic effects in this system might be produced not by daidzein or equol, but by biochanin A and/or genistein. In the Gf animals, the incidence of breast cancer was significantly higher in the biochanin A group than in the control group (p < 0.05), probably due to the increased level of estradiol in the former group. The biochanin A group tended to have a higher incidence of breast cancer than the daidzein group in the Gf group, although no significant differences were noted. Thus, no anticarcinogenic effect was produced by biochanin A alone in the Gf mice. In view of the results presented, genistein derived from biochanin A following metabolic processes in the intestinal microflora most likely acts as an inhibitor in breast carcinogenesis; biochanin A is most likely a precursor of genistein. Copyright 2002 S. Karger AG, Basel
机译：已知异黄酮具有抗癌作用。在小鼠乳腺肿瘤病毒（MMTV）诱导的自发性乳腺癌模型中，使用了两种异黄酮类生物素A和黄豆苷元检查了这些作用。重点是通过肠道微生物区系的异黄酮代谢和雌激素水平的变化。将无细菌（Gf）小鼠及其常规（Cv）对应小鼠分为三个饮食组：（1）对照饮食，（2）生物chanin A和（3）大豆苷元。在所有组中，从处女雌性小鼠中收集尿液，以通过高效液相色谱法分析异黄酮的代谢。这些研究表明，在Cv动物中，生物chanin A转变为染料木黄酮，而大豆苷元转变为雌马酚。但是，Gf小鼠无法将生物chanin A转化为染料木黄酮，或将大豆苷元转化为雌马酚。对照和大豆苷元饮食组中的雌激素水平在Gf小鼠中低于Cv小鼠。生物chanin A组在Cv和Gf动物之间未显示雌激素水平的差异。 Gf和Cv组将四周大的雄性和雌性动物配对。雌性动物反复分娩和泌乳，每周两次直到15个月大时，通过触诊观察到乳腺癌的发生。 Cv小鼠在生物chanin A饮食组中的乳腺癌发病率显着低于对照组或黄豆苷元组（p <0.05）。这些结果表明，该系统中的抗癌作用可能不是由大豆苷元或雌马酚产生的，而是由生物chanin A和/或染料木黄酮产生的。在Gf动物中，生物chanin A组的乳腺癌发病率显着高于对照组（p <0.05），这可能是由于前一组雌二醇水平升高所致。尽管没有发现明显的差异，但生物茶素A组的乳腺癌发病率往往比黄豆苷元组高。因此，在Gf小鼠中单独的生物chaninA没有产生抗癌作用。根据呈现的结果，源自肠道菌素A的金雀异黄素最有可能在乳腺癌致癌作用中起抑制作用。 biochanin A很可能是染料木黄酮的前体。版权所有2002 S. Karger AG，巴塞尔

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