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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Acridine orange excited by low-dose radiation has a strong cytocidal effect on mouse osteosarcoma.
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Acridine orange excited by low-dose radiation has a strong cytocidal effect on mouse osteosarcoma.

机译：低剂量辐射激发的啶橙对小鼠骨肉瘤具有很强的杀细胞作用。

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摘要

The study was conducted to clarify the cytocidal effect of combination therapy consisting of administration of acridine orange (AO), which is a photosensitizer, and radiation therapy using in vitro and in vivo mouse osteosarcoma models. The results revealed that AO combined with low-dose X-ray irradiation of about 1-5 Gy had a strong cytocidal effect on the cultured mouse osteosarcoma cells regardless of their chemosensitivity, and that this combination therapy inhibited growth of the in vivo mouse osteosarcoma by induction of tumor necrosis. This effect was inhibited by L-histidine, but not by mannitol. These findings suggested that AO might be excited by X-rays and kill osteosarcoma cells through the release of singlet oxygen, which is toxic to living cells. This mechanism is similar to that of photodynamic therapy with AO. Copyright 2002 S. Karger AG, Basel
机译：进行该研究以阐明组合疗法的杀细胞作用，该组合疗法包括使用光敏剂a啶橙（AO）和使用体外和体内小鼠骨肉瘤模型的放射疗法。结果表明，AO与低剂量X射线照射约1-5 Gy结合对培养的小鼠骨肉瘤细胞具有强的杀细胞作用，无论其化学敏感性如何，而且该联合疗法通过抑制VEGF抑制了体内小鼠骨肉瘤的生长。诱导肿瘤坏死。该作用被L-组氨酸抑制，但未被甘露醇抑制。这些发现表明，AO可能被X射线激发并通过释放单线态氧而杀死骨肉瘤细胞，而单线态氧对活细胞有毒。此机制类似于AO的光动力疗法。版权所有2002 S. Karger AG，巴塞尔

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