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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Primary lymphoma of bone--a retrospective study. Experience at the Northern Israel Oncology Center (1979-2000).
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Primary lymphoma of bone--a retrospective study. Experience at the Northern Israel Oncology Center (1979-2000).

机译：骨原发性淋巴瘤-一项回顾性研究。以色列北部肿瘤学中心的经验（1979年至2000年）。

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OBJECTIVE: This retrospective study describes our experience with the diagnosis, treatment, results and long-term follow-up of primary bone lymphoma (PBL). PATIENTS AND METHODS: Nineteen patients diagnosed with PBL were reviewed. Seven patients presented with stage I(E) disease, four with stage II(E) (regional lymphadenopathy), and eight with stage IV disease (disseminated bone involvement). Only one stage IV patient exhibited 'B' symptoms. The majority (72%) demonstrated diffuse, large cell, B-type lymphoma. All patients were treated with adriamycin-based chemotherapy and consolidation radiotherapy to the primary site (8 patients: early PBL) or the most bulky area (3 patients: stage IV PBL). RESULTS: Ten stage I(E)/II(E) patients are alive with no evidence of disease (NED) and only one died due to metastatic secondary lung cancer while with NED from his PBL. Eight stage IV patients are alive with NED. Median follow-up for all living patients: 77 months. Side effects were mild and did not necessitate delay in treatment. CONCLUSIONS: Our departmental policy of treating PBL patients with an anthracycline-based regimen and involved field radiotherapy proved to be successful in achieving excellent long-term, disease-free survival. Phase III randomized, controlled, clinical trials will determine the true role of consolidation radiotherapy in PBL, when considering severe late side effects, including radiation-induced bone tumors.
机译：目的：这项回顾性研究描述了我们在原发性骨淋巴瘤（PBL）的诊断，治疗，结果和长期随访方面的经验。病人和方法：对19名诊断为PBL的患者进行了回顾。七名患者患有I（E）期疾病，四名患者患有II（E）期（区域淋巴结病），八名患者患有IV期疾病（弥漫性骨受累）。仅一名IV期患者表现出“ B”症状。大多数（72％）表现为弥漫性大细胞B型淋巴瘤。所有患者均接受以阿霉素为基础的化学疗法和巩固放疗，以治疗原发部位（8例：早期PBL）或最大部位（3例：IV期PBL）。结果：十名I（E）/ II（E）期患者尚在世，没有疾病迹象（NED），只有一名因转移性继发性肺癌而死，而其PBL患有NED。八名IV期患者活着的是NED。所有存活患者的中位随访时间：77个月。副作用较轻，无需延迟治疗。结论：我们的部门政策以蒽环类为基础的方案治疗PBL患者，并涉及野外放疗，被证明可以成功地实现长期无病生存。考虑到严重的后期副作用，包括放射诱发的骨肿瘤，III期随机对照临床试验将确定巩固放疗在PBL中的真正作用。

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