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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer.
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Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer.

机译：p53免疫组化表达在胰腺癌患者中的预后价值。

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摘要

The prognostic value of the immunohistochemical expression of p53 was evaluated in 133 patients with pancreatic cancer. Formalin-fixed paraffin-embedded specimens of ductal pancreatic adenocarcinomas retrieved at the time of operation were stained with the monoclonal antibody DO-7. Approximately half of the tumors (47%) showed a high level of p53 immunoreactivity (> or = 20% positive nuclei). No correlation was demonstrated between the level of p53 immunoreactivity and age of the patient, gender, TNM stage, resectability or site of the tumor. A high level of p53 staining was seen in a slightly smaller proportion (30%) of patients with well-differentiated tumors than in patients with moderately (50%) or poorly differentiated (50%) tumors, but the difference was not significant. In a multivariate survival analysis, stage, grade and postoperative chemotherapy emerged as independent prognostic factors. Surgical resectability, if entered instead of stage as a variable in a separate Cox model, predicted prognosis independently. In univariate analysis, the site of the tumor was also a significant prognostic variable. However, no association between the level of p53 immunoreactivity and survival in either uni- or multivariate analysis was found.
机译：在133例胰腺癌患者中评估了p53免疫组织化学表达的预后价值。手术时取回的福尔马林固定的胰管腺癌石蜡包埋标本用单克隆抗体DO-7染色。大约一半的肿瘤（47％）显示出高水平的p53免疫反应性（≥20％阳性细胞核）。 p53免疫反应性水平与患者年龄，性别，TNM分期，可切除性或肿瘤部位之间无相关性。在高分化肿瘤患者中，p53染色的比例略低（30％），而在中度肿瘤（50％）或分化较差（50％）的患者中p53染色的比例较小，但差异不显着。在多因素生存分析中，阶段，分级和术后化疗是独立的预后因素。如果在一个单独的Cox模型中将手术可切除性作为变量而不是分阶段输入，则可手术预测其独立性。在单变量分析中，肿瘤部位也是重要的预后变量。但是，在单变量或多变量分析中均未发现p53免疫反应性水平与存活率之间存在关联。

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