首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Carboplatin as an anticancer agent for transcatheter arterial chemoembolization in patients with hepatocellular carcinoma.
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Carboplatin as an anticancer agent for transcatheter arterial chemoembolization in patients with hepatocellular carcinoma.

机译:卡铂作为肝癌患者经导管动脉化疗栓塞的抗癌药。

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摘要

Transcatheter arterial chemoembolization (TACE) is a conservative treatment in patients with hepatocellular carcinoma (HCC). In the present study, 30 patients with unresectable HCC underwent TACE using carboplatin (300 mg), and their clinical results were evaluated. After TACE, 18 (60.0%) of 30 patients demonstrated tumor size reduction rates > or = 50%. Of 23 patients with pretreatment serum alpha-fetoprotein (AFP) levels >20 ng/ml (cutoff), 14 (60.9%) showed AFP reduction > or = 75%. The 1-, 2-, 3- and 4-year survival rates were 82.9, 68.1, 45.1 and 37.6%, respectively. The median survival was 2.3 years. The only notable adverse reaction accompanying TACE was a transient myelosuppression. Carboplatin is thought to be a useful anticancer agent in patients with HCC treated with TACE.
机译:经导管动脉化疗栓塞(TACE)是肝细胞癌(HCC)患者的保守治疗。在本研究中,使用卡铂(300 mg)对30例无法切除的HCC患者进行了TACE,并对其临床结果进行了评估。 TACE后,30例患者中有18例(60.0%)肿瘤缩小率≥50%。在23名接受预处理的血清甲胎蛋白(AFP)水平> 20 ng / ml(临界值)的患者中,有14名(60.9%)的AFP降低≥75%。 1年,2年,3年和4年生存率分别为82.9、68.1、45.1和37.6%。中位生存期为2.3年。伴随TACE的唯一值得注意的不良反应是短暂性骨髓抑制。卡铂被认为是用TACE治疗的HCC患者的有用抗癌药。

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