Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

Sullivan M; Houslay MD; Olsen AS

首页> 外文期刊>Cellular Signalling >Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

【24h】

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

机译：人类环状AMP特异性磷酸二酯酶PDE4C基因的基因组组织及其在RAB3A和JUND之间的染色体定位，位于19p13.1。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

PDE4C is one of four mammalian genes that encode multiple PDE4 cyclic AMP-specific phosphodiesterase isoforms that are inhibited by rolipram. Fluorescent in situ hybridisation localised PDE4C to the p13.1 region of human chromosome 19. Overlapping cosmid clones spanning the human PDE4C gene were identified and characterised. Analysis of this locus indicated that the PDE4C gene spans at least 38 kb, consists of at least 18 exons, and contains the marker D19S212 within an intron. Comparison of published human PDE4C cDNA sequences with those of the genomic DNA identified four alternatively spliced exons and the possibility that the PDE4C locus contains at least three alternative promoters. PDE4C-containing cosmids also contained the genes for the growth regulatory transcription factor, JUND, and the mini guanine nucleotide regulatory protein, RAB3A. The RAB3A gene was shown to consist of 5 exons spanning 7.9 kb, while the JUND gene was found to contain no introns. Analysis of cosmids containing PDE4C, JUND, and RAB3A showed that 27 kb separate JUND and PDE4C, while only 3.7 kb separate PDE4C and RAB3A. The three genes share the same orientation of transcription and are arranged in the order cen- 5'- JUND-PDE4C-RAB3A-3'-tel.

机译：PDE4C是四个哺乳动物基因之一，其编码受咯利普兰抑制的多种PDE4环状AMP特异性磷酸二酯酶同工型。荧光原位杂交将PDE4C定位于人染色体19的p13.1区。鉴定并鉴定了跨越人PDE4C基因的重叠粘粒克隆。该基因座的分析表明，PDE4C基因跨至少38 kb，由至少18个外显子组成，并在内含子中包含标记D19S212。比较已发表的人PDE4C cDNA序列与基因组DNA的序列，可确定四个剪接的外显子，以及PDE4C基因座含有至少三个替代启动子的可能性。含有PDE4C的粘粒还含有生长调节转录因子JUND和微型鸟嘌呤核苷酸调节蛋白RAB3A的基因。结果表明，RAB3A基因由5个跨度为7.9 kb的外显子组成，而JUND基因不含内含子。对含有PDE4C，JUND和RAB3A的粘粒的分析表明，分别有27 kb的JUND和PDE4C分开，而只有3.7 kb的PDE4C和RAB3A分开。这三个基因共享相同的转录方向，并以cen-5'- JUND-PDE4C-RAB3A-3'-tel的顺序排列。

著录项

来源
《Cellular Signalling》 |1999年第10期|共8页
作者
Sullivan M; Houslay MD; Olsen AS;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类细胞形态学;
关键词
rab3A GTP-Binding Protein: Genetics; Base Sequence; Chromosome Mapping; Chromosomes; Human; Pair 19; Cyclic AMP: Metabolism; DNA; Complementary; Human; Molecular Sequence Data; Substrate Specificity; 3'; 5'-Cyclic-Nucleotide Phosphodiesterase: Genetics; 3'; 5'-Cyclic-Nucleotide Phosphodiesterase: Metabolism;

机译：rab3A GTP结合蛋白：遗传;碱基序列;染色体定位;染色体;人类;对19;循环AMP：代谢;DNA;互补;人类;分子序列数据;底物特异性;3';5'-环状核酸磷酸二酯酶：遗传学;3';5'-环核苷酸磷酸二酯酶：代谢;

相似文献

外文文献
中文文献
专利

1. Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND. [J] . Sullivan M, Houslay MD, Olsen AS Cellular Signalling . 1999,第10期

机译：人类环状AMP特异性磷酸二酯酶PDE4C基因的基因组组织及其在RAB3A和JUND之间的染色体定位，位于19p13.1。
2. Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10. [J] . Rena G, Begg F, Ross A, Molecular pharmacology. . 2001,第5期

机译：分子克隆，基因组定位，启动子鉴定和新型环状amp特异性磷酸二酯酶PDE4A10的表征。
3. Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast [J] . M D Houslay, M Sullivan, M Wilson, The biochemical journal . 1994,第2期

机译：咯利普兰抑制酵母中表达的人IVA型环状AMP特异性磷酸二酯酶的纯化，表征和分析
4. Cyclic AMP-Specific Phosphodiesterase Inhibitor Promote Protein Synthesis of Primary Skeletal Muscle Cells Cultured in vitro [C] . The First Academic Conference of Asian Society of Traditional Veterinary Medicine(首届亚洲兽医传统医学会学术研讨会)论文集 . 2006

机译：环状AMP特异性磷酸二酯酶抑制剂促进体外培养的骨骼肌细胞蛋白质合成。
5. Chromosomal Scale Length Variations as a Genetic Risk Score for Predicting Complex Human Diseases in Large Scale Genomic Datasets [D] . Toh, Christopher En-Li. 2021

机译：作为预测大规模基因组数据集中复杂人类疾病的遗传风险分数作为遗传风险分数的染色体刻度
6. Purification characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast. [O] . M Wilson, M Sullivan, N Brown, 1994

机译：纯化表征和分析咯利普兰抑制酵母中表达的人IVA型环AMP特异性磷酸二酯酶。
7. Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. [O] . Conti, Marco, Richter, Wito, Méhats, Céline, 2003

机译：环状AMP特异性PDE4磷酸二酯酶是环状AMP信号传导的关键组成部分。

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

摘要

著录项

相似文献

相关主题

期刊订阅