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首页> 外文期刊>Reproductive toxicology >Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases.
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Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases.

机译：妊娠引起的Th2免疫偏离：自身免疫性风湿性疾病的两方面。

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One of the most important immunological modifications during pregnancy is the Th1/Th2 shift, due to the progressive increase of progesterone and estrogens during pregnancy, which reach their peak-level in the third trimester of gestation. At high levels, estrogens seem mainly to suppress Th1 cytokines and stimulate Th2-mediated immunological responses as well as antibody production. For this reason Th1-mediated diseases, like rheumatoid arthritis (RA), tend to improve and Th2-mediated disease, like systemic lupus erythematosus (SLE), tend to worsen during pregnancy. SLE is the autoimmune rheumatic disease in which pregnancy most frequently occurs because it predominantly affects young females in their childbearing age. Other autoimmune rheumatic diseases, including RA, are less frequently observed during pregnancy due to their low female-to-male ratio and peak onset after the age of 40. This review is focused on the disease course, gestational outcome and management of patients with SLE and RA during pregnancy.
机译：妊娠期间最重要的免疫学修饰之一是Th1 / Th2转移，这是由于妊娠期间孕酮和雌激素的逐渐增加所致，并在妊娠晚期达到了最高水平。在高水平下，雌激素似乎主要抑制Th1细胞因子并刺激Th2介导的免疫反应以及抗体产生。因此，Th1介导的疾病（如类风湿性关节炎（RA））趋于改善，而Th2介导的疾病（如系统性红斑狼疮（SLE））在怀孕期间趋于恶化。 SLE是一种自身免疫性风湿性疾病，其中妊娠最频繁，因为它主要影响育龄女性的年龄。其他自身免疫性风湿性疾病，包括RA，由于其男女比例低，且在40岁后发病高峰，因此在妊娠期较少见。该综述集中于SLE患者的病程，妊娠结局和管理和怀孕期间的RA。

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