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首页> 外文期刊>Reproductive toxicology >Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats.
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Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats.

机译：邻苯二甲酸二异壬酯（DINP）在围产期暴露的大鼠中的生殖和行为影响。

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摘要

Diisononyl phthalate (DINP) is a plasticizer abundantly used in consumer products as a substitute for other plasticizers prohibited in certain products due to reproductive toxicity. As anti-androgenic effects of DINP are suspected, DINP effects on reproduction and sexually dimorphic behavior were studied. Pregnant Wistar rats were gavaged from gestation day 7 to postnatal day (PND) 17 with vehicle, 300, 600, 750 or 900 mg DINP/kg bw/day. In fetal testes histopathological effects typical of phthalates were observed. In male offspring, DINP caused increased nipple retention, reduced anogenital distance, reduced sperm motility and increased sperm count. DINP affected spatial learning as female offspring performed better than controls and similarly to control males in the Morris Water Maze, indicating masculinization of behavior in DINP exposed females. These results show that DINP causes anti-androgenic effects on reproductive development, though less potent than DEHP, DBP and BBP, and further safety evaluation of DINP appears warranted.
机译：邻苯二甲酸二异壬酯（DINP）是一种增塑剂，在消费产品中被广泛使用，以替代某些产品由于生殖毒性而被禁止的其他增塑剂。由于怀疑DINP具有抗雄激素作用，因此研究了DINP对生殖和性二态行为的影响。从妊娠第7天到出生后第17天（PND），以300、600、750或900 mg DINP / kg bw /天对Wistar怀孕大鼠进行管饲。在胎儿睾丸中，观察到典型邻苯二甲酸盐的组织病理学作用。在雄性后代中，DINP导致乳头retention留增加，肛门生殖器距离缩短，精子活动力降低和精子数量增加。 DINP影响了空间学习，因为在Morris水迷宫中，雌性后代的表现优于对照，并且与对照雄性相似，这表明暴露于DINP的雌性行为的男性化。这些结果表明，DINP对生殖发育具有抗雄激素作用，尽管其效力不及DEHP，DBP和BBP，并且有必要进一步评估DINP的安全性。

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