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首页> 外文期刊>Reproductive toxicology >Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse.
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Stage-dependent abnormalities induced by the fungicide triadimefon in the mouse.

机译：由杀真菌剂三唑酮在小鼠中诱发的阶段依赖性异常。

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摘要

Aim of this work is the study of abnormalities induced by the triazole triadimefon (FON) administered to pregnant mice at E8, E9, E10, E11 or E12. Pregnant CD-1 mouse were gavaged with FON 500 mg/kg at the selected stages and sacrificed at term and fetuses morphologically examined and processed for visceral and skeletal analysis. Administration of FON on E8, E10-E12 resulted in fetuses with cleft palate (E8 39% and E12 24% representing the peak of sensitivity, in E8 fetuses associated to severe skull basis abnormalities). Other cranial malformations (fusions abnormalities or agenesis of bones) were observed in E8-E10 groups (E8 the most sensitive with 96% of malformed fetuses). Cardiovascular abnormalities were observed in a stage dependent manner at E8-E10 (22.2, 3.8, 7.8%). As far as craniofacial malformation is concerned, we propose that FON acts on two different stages, involved in early and late craniofacial formation.
机译：这项工作的目的是研究对怀孕小鼠在E8，E9，E10，E11或E12施用三唑三唑酮（FON）引起的异常。在选定的阶段用500 mg / kg的FON灌胃怀孕的CD-1小鼠，并在足月处死，对胎儿进行形态学检查，并进行内脏和骨骼分析。在E8，E10-E12上施用FON会导致胎儿with裂（与严重颅底异常相关的E8胎儿中E8的敏感性为39％，E12的敏感性为24％）。在E8-E10组中观察到其他颅骨畸形（融合异常或骨骼发育不良）（E8对96％畸形胎儿最敏感）。在E8-E10阶段以阶段依赖性的方式观察到心血管异常（22.2、3.8、7.8％）。就颅面畸形而言，我们建议FON作用于颅面早期和晚期形成的两个不同阶段。

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