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首页> 外文期刊>Reproductive toxicology >Effects of multiple doses of cyclophosphamide on mouse testes: accessing the germ cells lost, and the functional damage of stem cells.
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Effects of multiple doses of cyclophosphamide on mouse testes: accessing the germ cells lost, and the functional damage of stem cells.

机译：多剂量环磷酰胺对小鼠睾丸的影响：进入失去的生殖细胞，以及干细胞的功能损伤。

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摘要

Spermatogenesis is sensitive to the chemotherapeutic drug cyclophosphamide, which decreases the patients' sperm count. Since the recovery of fertility is dependent on regeneration from stem cells, in the present study we evaluated the ability of cyclophosphamide-exposed stem spermatogonia from mice to regenerate spermatogenesis in situ and after transplantation. When seven doses of cyclophosphamide were given at 4-day intervals, the differentiating germ cells were largely eliminated but ~50% of the undifferentiated type A spermatogonia remained. We monitored the recovery and found that sperm production recovered to 64% of control within the time expected. When the cyclophosphamide-surviving spermatogonia were transplanted into recipient mice, recovery of spermatogenesis from the cyclophosphamide-exposed donor cells was observed, but was reduced when compared to cells from cryptorchid donors. Thus, multidose regimens of cyclophosphamide did not eliminate the stem spermatogonia, but resulted in cell loss and residual damage.
机译：精子发生对化学治疗药物环磷酰胺敏感，这会减少患者的精子数量。由于生育能力的恢复取决于干细胞的再生，因此在本研究中，我们评估了暴露于环磷酰胺的小鼠干精原细胞在原位和移植后再生精子的能力。当每隔4天服用7剂环磷酰胺时，分化中的生殖细胞被大量清除，但仍保留了约50％的未分化A型精原细胞。我们监测了恢复情况，发现精子产量在预期时间内恢复了控制的64％。当将存活环磷酰胺的精原细胞移植到受体小鼠中时，观察到了从暴露于环磷酰胺的供体细胞中精子发生的恢复，但与隐睾供体的细胞相比，精子发生的恢复降低了。因此，多剂量的环磷酰胺治疗不能消除干细胞精原细胞，但会导致细胞损失和残余损伤。

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