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首页> 外文期刊>Reproductive toxicology >Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy.
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Adverse effects on development of the reproductive system in male offspring of rats given monobutyl phthalate, a metabolite of dibutyl phthalate, during late pregnancy.

机译：妊娠后期服用邻苯二甲酸单丁酯（一种邻苯二甲酸二丁酯的代谢产物）对大鼠雄性后代生殖系统发育的不利影响。

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摘要

The objective of this study was to determine the adverse effects of monobutyl phthalate (MBuP), a major metabolite of dibutyl phthalate (DBP), on development of the reproductive system in offspring following maternal administration during late pregnancy, and to assess the role of MBuP in the antiandrogenic effects of DBP. Pregnant rats were given MBuP by gastric intubation at 250, 500, or 750 mg/kg on days 15 through 17 of pregnancy. Maternal body weight gain and food consumption during the administration period were significantly decreased at 500 mg/kg and higher and at 750 mg/kg, respectively. A significant increase in the incidence of postimplantation embryonic loss was found at 500 mg/kg and higher. The body weights of male and female fetuses were significantly lower at 750 mg/kg. A significant increase in the incidence of fetuses with undescended testes was found at 250 mg/kg and higher. A significant decrease in the anogenital distance (AGD) of male fetuses was observed at 250 mg/kg and higher. The AGD/body weight ratio and AGD/cube root of body weight ratio in male fetuses was also significantly reduced at 250 mg/kg and higher. The AGD, AGD/body weight ratio and AGD/cube root of body weight ratio in female fetuses in the MBuP-treated groups were comparable to those in the control group. The present study indicates that MBuP on days 15 to 17 of pregnancy produced adverse effects on the development of reproductive system in male offspring and suggest that MBuP may be responsible for the induction of the antiandrogenic effects of DBP.
机译：这项研究的目的是确定邻苯二甲酸二丁酯（DBP）的主要代谢物邻苯二甲酸单丁酯（MBuP）对妊娠晚期孕妇产后后代生殖系统发育的不利影响，并评估MBuP的作用。 DBP的抗雄激素作用。在怀孕的第15至17天，通过胃插管以250、500或750 mg / kg的剂量给怀孕的大鼠MBuP。服用期间孕妇的体重增加和食物消耗分别显着降低，分别为500 mg / kg和更高和750 mg / kg。在500 mg / kg或更高的剂量下，发现植入后胚胎丢失的发生率显着增加。男性和女性胎儿的体重明显降低，为750 mg / kg。 250 mg / kg或更高的胎儿睾丸未降的发生率显着增加。在250 mg / kg或更高的剂量下，雄性胎儿的肛门生殖距离（AGD）显着降低。 250 mg / kg或更高时，雄性胎儿的AGD /体重比和AGD /立方根体重比也显着降低。 MBuP治疗组的女性胎儿的AGD，AGD /体重比和AGD /立方根体重比与对照组相当。本研究表明，妊娠15至17天的MBuP对雄性后代的生殖系统发育产生不利影响，并暗示MBuP可能是诱导DBP抗雄激素作用的原因。

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