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首页> 外文期刊>Reproductive toxicology >Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy.
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Effects on development of the reproductive system in male offspring of rats given butyl benzyl phthalate during late pregnancy.

机译：妊娠后期服用邻苯二甲酸丁苄酯对大鼠雄性后代生殖系统发育的影响。

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摘要

The objective of this study was to determine the effects of maternal exposure to butyl benzyl phthalate (BBP) on the development of the reproductive system in male offspring. Pregnant rats were given BBP by gastric intubation at 250, 500, or 1000 mg/kg on days 15 to 17 of pregnancy. A significant decrease in maternal body weight gain and food consumption was found in rats given BBP at 500 and 1000 mg/kg. A significant decrease in the number of live fetuses per litter was found at 1000 mg/kg. The weights of male and female fetuses were significantly decreased in the groups given BBP at 1000 mg/kg. A significant increase in the incidence of fetuses with undescended testes was found at 500 and 1000 mg/kg. A significant decrease in the anogenital distance (AGD) of male fetuses was observed at 500 and 1000 mg/kg. The AGD/cube root of body weight ratio in male fetuses was also significantly reduced at 500 mg/kg and higher. The AGD and AGD/cube root of body weight ratio of female fetuses in the BBP-treated groups were comparable to those in the control group. It was concluded that BBP on days 15 to 17 of pregnancy produced adverse effects on the development of the reproductive system in male offspring.
机译：这项研究的目的是确定母体暴露于邻苯二甲酸丁苄酯（BBP）对雄性后代生殖系统发育的影响。在怀孕的第15至17天，通过胃插管以250、500或1000 mg / kg的剂量给怀孕的大鼠BBP。在以500和1000 mg / kg的BBP服用的大鼠中，孕妇的体重增加和食物消耗显着降低。发现每窝活胎儿的数量以1000 mg / kg显着减少。在以1000 mg / kg给予BBP的组中，男女胎儿的体重显着降低。睾丸未降的胎儿发病率显着增加，为500和1000 mg / kg。在500和1000 mg / kg时，观察到雄性胎儿的肛门生殖距离（AGD）明显减少。男性胎儿体重比的AGD /立方根在500 mg / kg或更高时也显着降低。 BBP治疗组的女性胎儿的AGD和AGD /立方根体重比与对照组相当。结论是，怀孕15至17天的BBP对雄性后代的生殖系统发育产生了不利影响。

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