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首页> 外文期刊>Reproductive toxicology >Effect of human chorionic gonadotrophin coadministration on ovarian steroidogenic and folliculogenic activities in cyclophosphamide treated albino rats.
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Effect of human chorionic gonadotrophin coadministration on ovarian steroidogenic and folliculogenic activities in cyclophosphamide treated albino rats.

机译：人绒毛膜促性腺激素共同给药对环磷酰胺治疗的白化病大鼠卵巢类固醇生成和卵泡生成活性的影响。

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摘要

Quantitative evaluation of ovarian Delta5,3beta- hydroxysteroid dehydrogenese (HSD) and 17beta - HSD activities along with radioimmunoassay of plasma levels of gonadotrophins (FSH and LH), and estradiol (E2), and quantification of different types of developing follicles and regressive follicles were noted in mature rats of the Wistar strain following treatment with cyclophosphamide at a dose of 5 mg/kg body weight/day for 28 days. A significant reduction in plasma levels of LH and E2 along with significant diminution in the activities of ovarian Delta5,3beta -HSD and 17beta- HSD were observed following cyclophosphamide treatment for 28 days without any change in the plasma level of FSH. This treatment also produced a marked degree of degeneration in different types of follicles. Coadministration of hCG at 5 IU/kg body weight/day for 28 days in the cyclophosphamide-treated group provided significant protection except with respect to plasma LH. These results suggest the possibility of an indirect action of cyclophosphamide at the level of the ovary.
机译：定量评估卵巢Delta5,3β-羟基类固醇脱氢酶（HSD）和17β-HSD活性以及放射免疫法测定血浆促性腺激素（FSH和LH）和雌二醇（E2）的水平，并对不同类型的发育卵泡和退化卵泡进行定量在用环磷酰胺以5 mg / kg体重/天的剂量治疗28天后，在Wistar品系的成熟大鼠中发现“白喉病”。在环磷酰胺治疗28天后，未观察到LH和E2的血浆水平显着降低，卵巢Delta5,3beta -HSD和17beta-HSD活性显着降低，但FSH血浆水平未发生任何变化。这种治疗还使不同类型的卵泡发生明显程度的变性。在环磷酰胺治疗组中，以5 IU / kg体重/天的hCG共同给药28天可提供明显的保护作用，但血浆LH除外。这些结果表明环磷酰胺在卵巢水平上有间接作用的可能性。

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