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首页> 外文期刊>Reproductive toxicology >Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats.
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Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats.

机译：饮食和管饲法对Sprague Dawley大鼠进行大豆异黄酮染料木黄酮的胎盘转移。

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摘要

Genistein, the principal soy isoflavone, has estrogenic activity and is widely consumed by humans for putative beneficial health effects. The goal of the present study was to measure placental transfer of genistein in rats as a possible route of developmental exposure. Pregnant Sprague-Dawley rats were administered genistein orally, either by diet or by gavage. Concentrations of genistein aglycone and conjugates were measured in maternal and offspring serum and brain using HPLC with isotope dilution electrospray tandem mass spectrometry. Although fetal or neonatal serum concentrations of total genistein were approximately 20-fold lower than maternal serum concentrations, the biologically active genistein aglycone concentration was only 5-fold lower. Fetal brain contained predominately genistein aglycone at levels similar to those in the maternal brain. These studies show that genistein aglycone crosses the rat placenta and can reach fetal brain from maternal serum genistein levels that are relevant to those observed in humans.
机译：金雀异黄素是大豆异黄酮的主要成分，具有雌激素活性，被人类广泛食用以产生有益的健康效果。本研究的目的是测量染料木素在大鼠中的胎盘转移，作为发育性暴露的可能途径。通过饮食或管饲法给怀孕的Sprague-Dawley大鼠口服染料木黄酮。使用HPLC和同位素稀释电喷雾串联质谱法测定母体和后代血清和脑中的染料木黄酮苷元和结合物的浓度。尽管胎儿或新生儿中总染料木黄酮的浓度比母亲血清中的浓度低约20倍，但具有生物活性的染料木黄酮苷元的浓度仅低5倍。胎儿脑中主要含有染料木黄酮苷元，含量与孕产妇脑中相似。这些研究表明，染料木黄酮苷元可以穿过大鼠胎盘，并可以通过与人类观察到的母源血清染料木黄酮水平相关的途径到达胎儿大脑。

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