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首页> 外文期刊>Reproductive toxicology >Reproductive effects of nonylphenol in rats after gavage administration: a two-generation study.
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Reproductive effects of nonylphenol in rats after gavage administration: a two-generation study.

机译：灌胃给药后壬基酚对大鼠的生殖作用：两代研究。

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The potential reproductive toxicity of nonylphenol (NP) was assessed in a two-generation reproductive toxicity study. Groups of 25 male and female Crj:CD (SD) IGS rats were given NP by gavage at levels of 2, 10, or 50 mg/kg, and 25 males and females were given corn oil as controls. No adverse changes in clinical signs were observed in any rats throughout the study. Significant increases in the liver, kidney and pituitary gland weights in males, and decreases in thymus weight in males and in ovary weight in females were observed in the 50 mg/kg group. NP did not affect sperm characteristics or the estrous cycle at any dose administered. A significant increase in the TSH level was observed in males in the 50 mg/kg group. No adverse effects of NP on reproduction were found. At necropsy, no treatment-related alterations were observed in any organs including the reproductive tissues in any group. Histopathologic changes were found in the liver of male and female rats and kidneys of males in the 50 mg/kg group. The viability of offspring from postnatal day 0 to 4 in the 50 mg/kg group was reduced as compared with that in the controls, although growth was not affected by NP administration. On postnatal day 22, an increase in the serum FSH level and decrease in T(3) level for males, and decreases in LH and TSH levels and an increase in T(3) levels for females were observed in the 50 mg/kg group. NP did not affect the timing of preputial separation, while vaginal opening was accelerated in the 50 mg/kg group. No adverse changes were found in behavior or learning in the offspring of NP-treated groups. There were no treatment-related changes in any reproductive parameter, including estrous cycle, mating, fertility, delivery, and lactation, except for significant decreases in the numbers of implantation sites and live pups, and a significant decrease in ovary weight in the 50 mg/kg group. Kidney and liver weight were increased in males in the 50 mg/kg group. Histopathologic examination revealed changes in the liver of males and females of the 50 mg/kg group. No treatment-related changes were observed in the sperm characteristics. Hormone data should be interpreted cautiously until the findings are repeated and confirmed by further studies. These results of NP suggested that the no observed adverse effect level (NOAEL) on reproductive capacity is 50 mg/kg/day or greater in parent animals, and 10 mg/kg/day in the next generation under the present experimental condition.
机译：在两代生殖毒性研究中评估了壬基酚（NP）的潜在生殖毒性。每组25只雄性和雌性Crj：CD（SD）IGS大鼠通过管饲法分别以2、10或50 mg / kg的水平给予N​​P，并且将25只雄性和雌性的玉米油作为对照。在整个研究中，在任何大鼠中均未观察到临床症状的不利变化。在50 mg / kg组中，雄性的肝脏，肾脏和垂体重量显着增加，雄性的胸腺重量降低，雌性的卵巢重量降低。 NP在任何剂量下均不影响精子特征或发情周期。在50 mg / kg组中，男性的TSH水平显着增加。没有发现NP对繁殖的不利影响。尸检时，在任何器官，包括任何组中的生殖组织，均未观察到与治疗相关的改变。在50 mg / kg组中，在雄性和雌性大鼠的肝脏以及雄性的肾脏中发现了组织病理学变化。与对照组相比，50 mg / kg组从出生后第0天到第4天的后代活力降低了，尽管其生长不受NP施用的影响。出生后第22天，在50 mg / kg组中，男性血清FSH水平升高，T（3）水平降低，女性LH和TSH水平降低，女性T（3）水平升高。 。 NP不影响包皮分离的时机，而50 mg / kg组的阴道开放速度加快。在NP治疗组的后代中没有发现行为或学习方面的不利变化。除植入部位和活仔的数量显着减少以及50 mg的卵巢重量显着减少外，任何生殖参数（包括发情周期，交配，生育力，分娩和泌乳）均没有与治疗相关的变化。 / kg组。 50 mg / kg组的男性肾脏和肝脏重量增加。组织病理学检查显示50 mg / kg组的男性和女性肝脏发生变化。没有观察到与治疗有关的精子特征变化。激素数据应谨慎解释，直到重复发现并进一步研究证实。 NP的这些结果表明，在本实验条件下，在亲本动物中未观察到的对生殖能力的不良影响水平（NOAEL）为50 mg / kg /天或更高，在下一代中为10 mg / kg /天。

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