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首页> 外文期刊>Reproductive toxicology >Effect of L-arginine on arginase activity in male accessory sex glands of alloxan-treated rats.
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Effect of L-arginine on arginase activity in male accessory sex glands of alloxan-treated rats.

机译：L-精氨酸对四氧嘧啶处理的大鼠雄性性腺中精氨酸酶活性的影响。

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摘要

Arginase activity has been identified in the prostate, and may be important in the synthesis of polyamines in accessory sex glands in the male. Polyamines in turn may mediate the action of androgens. Diabetic patients have disordered androgen synthesis. The purpose of this work was to evaluate the effect of L-arginine on arginase activity in accessory sex glands of male rats under normal and diabetic conditions (alloxan 120 mg/kg, i.p.). Normal and diabetic male rats were untreated or were treated with insulin or L-arginine for 96 h, and sacrificed. Arginase activity was measured in serum and in accessory sex glands. Arginase activity in accessory glands did not change significantly with induction of diabetes. Arginase activity was increased in diabetic insulin-treated rats, but there was no arginase response to L-arginine administration in diabetic animals. These findings stand in contrast to beneficial effects of L-arginine previously observed when this amino acid was administered for a long time (atleast 10 days). We suspect that altered arginase activity in accessory sex glands may play a role in the reproductive dysfunction caused by diabetes, inasmuch as arginase activity can be increased in experimentally diabetic rats by the administration of insulin.
机译：精氨酸酶活性已经在前列腺中被鉴定，并且可能在男性的附属性腺中多胺的合成中很重要。反过来，多胺可能介导雄激素的作用。糖尿病患者的雄激素合成异常。这项工作的目的是评估在正常和糖尿病条件下（四氧嘧啶120 mg / kg，腹腔注射）L-精氨酸对雄性大鼠副性腺中精氨酸酶活性的影响。正常和糖尿病雄性大鼠未经治疗或用胰岛素或L-精氨酸治疗96小时，并处死。在血清和辅助性腺中测量精氨酸酶活性。附属腺中的精氨酸酶活性没有随诱导糖尿病而显着变化。在糖尿病胰岛素治疗的大鼠中，精氨酸酶活性增加，但是在糖尿病动物中，对L-精氨酸的给药没有精氨酸酶反应。这些发现与长期（至少10天）施用该氨基酸时先前观察到的L-精氨酸的有益作用相反。我们怀疑附属性腺中精氨酸酶活性的改变可能在糖尿病引起的生殖功能障碍中起作用，因为在实验性糖尿病大鼠中施用胰岛素可以提高精氨酸酶的活性。

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