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首页> 外文期刊>Reproductive toxicology >Effects of metronidazole, ipronidazole, and dibromochloropropane on rabbit and human sperm motility and fertility.
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Effects of metronidazole, ipronidazole, and dibromochloropropane on rabbit and human sperm motility and fertility.

机译：甲硝唑，异丙硝唑和二溴氯丙烷对兔和人精子运动和受精的影响。

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摘要

Treatment of protozoal pathogens in the reproductive system with chemical agents exposes flagellated sperm cells to potential toxicants. A widely used antiprotozoal agent is metronidazole. Its effect on rabbit and human sperm was compared with a more soluble 5-nitroazole compound, ipronidazole, and with a systemic environmental toxicant, dibromochloropropane (DBCP). The percentages of motile rabbit and human sperm incubated with the compounds, the velocity of sperm, migration of sperm in polyacrylamide gel, young born in rabbits, and penetration of hamster oocytes by treated human sperm were measured in seven experiments. Up to 10mg/ml metronidazole and 1mg/ml DBCP had little effect on most sperm characteristics. However, 10mg/ml metronidazole and 5mg/ml of ipronidazole increased attachment of human sperm to hamster oocytes, but oocyte penetration was unaffected. Rabbit sperm exposed to 5mg/ml ipronidazole were infertile. No oocytes were penetrated by DBCP-treated human sperm.
机译：用化学试剂处理生殖系统中的原生动物病原体会使鞭毛精子细胞暴露于潜在的毒物。广泛使用的抗原生动物剂是甲硝唑。将其对兔和人精子的作用与可溶性更强的5-硝基唑化合物ipronidazole以及全身性环境毒性二溴氯丙烷（DBCP）进行了比较。在七个实验中，测量了用该化合物孵育的活动性兔子和人类精子的百分比，精子的速度，聚丙烯酰胺凝胶中精子的迁移，家兔的幼龄以及仓鼠卵母细胞被处理过的人类精子的渗透率。高达10mg / ml的甲硝唑和1mg / ml的DBCP对大多数精子特征影响很小。然而，10mg / ml甲硝唑和5mg / ml ipronidazole会增加人精子对仓鼠卵母细胞的附着力，但卵母细胞渗透率不受影响。暴露于5mg / ml ipronidazole的兔精子不育。 DBCP处理的人类精子没有渗透卵母细胞。

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