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首页> 外文期刊>Reproductive toxicology >Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D((R)) (2,4-dichlorophenoxyacetic acid and picloram) in rats.
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Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D((R)) (2,4-dichlorophenoxyacetic acid and picloram) in rats.

机译：长期暴露于大鼠中的除草剂制剂Tordon 75D（R）（2,4-二氯苯氧基乙酸和吡咯仑）引起的睾丸变化。

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摘要

The second most used herbicide in the Vietnam war was Agent White, which contained the active components 2,4-dichlorophenoxyacetic acid (2,4-D) and 4-amino-3,5,6-trichloropicolinic acid (picloram). The herbicide formulation Tordon 75D((R)) is similar in terms of its active components to Agent White and is currently used by the agricultural industry in Australia. As part of an investigation into the possible adverse effects of this herbicide on male reproductive performance, groups of five male rats were gavaged 5 days a week for 9 weeks with either 0.125ml/kg (low dose), 0.25ml/kg (middle dose), or 0.5ml/kg (high dose) Tordon 75D((R)) or water (controls). The high dose corresponded to 150mg/kg body weight 2,4-D and 37.5mg/kg picloram acid equivalents. At the end of the treatment period, the testes were collected, weighed, and examined histologically and blood samples were taken to determine serum testosterone. Groups of high dose animals were also examined after 1, 2, and 4 weeks treatment. The 9 weeks treatment with Tordon 75D((R)) caused severe reduction in testicular weight in some high dose animals. Histologically, the small testes showed shrunken tubules with germ cell depletion. This damage was still evident in some rats following a 21 weeks recovery period suggesting that the testicular damage was permanent. Testicular damage was not due to endocrine disruption as there were no significant differences in the serum concentration of testosterone in control animals compared to Tordon 75D((R))-treated animals. Blood levels associated with the high dose were determined in a separate study and were much higher than those likely to be obtained by occupational exposure to this herbicide.
机译：越南战争中使用次数最多的除草剂是White特工，它含有2,4-二氯苯氧基乙酸（2,4-D）和4-氨基-3,5,6-三氯吡啶甲酸（picloram）的活性成分。除草剂配方Tordon 75D（R）的活性成分与特工White相似，目前在澳大利亚的农业中使用。作为对该除草剂可能对雄性生殖性能产生不利影响的调查的一部分，将五只雄性大鼠的组每周5天连续灌胃9周，剂量分别为0.125ml / kg（低剂量），0.25ml / kg（中剂量） ）或0.5ml / kg（大剂量）Tordon 75D（R）或水（对照）。高剂量对应于150mg / kg体重的2，4-D和37.5mg / kg吡咯烷酸当量。在治疗期结束时，收集睾丸，称重，并进行组织学检查，并采集血样以确定血清睾丸激素。在1、2和4周的治疗后还检查了高剂量动物组。用Tordon 75D（R）进行的9周治疗导致某些高剂量动物的睾丸重量严重减少。从组织学上看，小睾丸显示肾小管缩小，生殖细胞耗竭。在恢复21周后，这种损伤在某些大鼠中仍然很明显，这表明睾丸损伤是永久性的。睾丸损伤不是由于内分泌干扰引起的，因为与用Tordon 75D（-）处理的动物相比，对照动物的睾丸激素血清浓度没有显着差异。与高剂量相关的血液水平在另一项研究中确定，远高于通过职业性接触该除草剂而可能获得的水平。

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