Juvenile toxicity of cyclosporin in the rat.

Allais L; Condevaux F; Fant P; Barrow PC

首页> 外文期刊>Reproductive toxicology >Juvenile toxicity of cyclosporin in the rat.

【24h】

Juvenile toxicity of cyclosporin in the rat.

机译：环孢菌素在大鼠中的少年毒性。

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The pups from 32 litters of SD rats were given 0, 1, 3 or 10mg/kg-d of cyclosporin by oral gavage from 4 to 28 days of age. 10mg/kg-d resulted in a persistent impairment of the primary antibody response at 10 weeks of age. Indications of systemic toxicity, including the death of 10/64 pups and severely depressed weight gain, were also observed at this dose level. Arteriopathy of the heart and tubular basophilia and edema in the cortico-medullary region of the kidney were observed at 3 and 10mg/kg-d. In conclusion, while pharmacological effects were seen at all dose levels, the adverse effects of cyclosporin on the development of the immune system in the rat only occurred at a dose level that also induced systemic toxicity.

机译：通过从4至28日龄的管饲法，对32只SD大鼠的幼崽口服给予0、1、3或10mg / kg-d的环孢菌素。 10mg / kg-d在10周龄时导致一抗反应持续性损伤。在该剂量水平下，还观察到全身毒性的迹象，包括10/64幼崽的死亡和体重增加的严重下降。以3mg / kg-d和10mg / kg-d的剂量观察到心脏的动脉病变和肾皮质-髓质区域的肾小管嗜碱性和水肿。总之，尽管在所有剂量水平上都可以看到药理作用，但环孢菌素对大鼠免疫系统发育的不良影响仅在也能引起全身毒性的剂量水平下发生。

著录项

来源
《Reproductive toxicology》 |2009年第2期|共9页
作者
Allais L; Condevaux F; Fant P; Barrow PC;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词

相似文献

外文文献
中文文献
专利

1. Juvenile toxicity of cyclosporin in the rat. [J] . Allais L, Condevaux F, Fant P, Reproductive toxicology . 2009,第2期

机译：环孢菌素在大鼠中的少年毒性。
2. Experimental nephrotoxicity, hepatotoxicity and pharmacokinetics of cyclosporin G versus cyclosporin A [J] . Emmanuel A Burdmann, Takeshi F Andoh, Seymour Rosen, Kidney international. . 1994,第3期

机译：环孢菌素G与环孢菌素A的实验肾毒性，肝毒性和药代动力学
3. Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin [J] . A P Halestrap, E J Griffiths The biochemical journal . 1991,第2期

机译：进一步的证据表明，环孢菌素A通过抑制基质肽基-脯氨酰顺反异构酶来保护线粒体免受钙超载。对环孢菌素的免疫抑制和毒性作用的影响
4. ACUTE TOXICITY OF AMMONIA ON JUVENILE BELUGA STURGEON Huso huso [C] . Mahan Salamroodi, Bahram Falahatkar Annual Meeting of the European Aquaculture Society . 2013

机译：少年白米达鲟鱼哈索侯急性毒性
5. An investigation of the effects of compounds structurally related to L-cysteine and taurine on acetaminophen-induced hepatotoxicity and nephrotoxicity in the rat. [D] . Acharya, Miteshkumar. 2009

机译：研究与L-半胱氨酸和牛磺酸结构相关的化合物对乙酰氨基酚诱导的大鼠肝毒性和肾毒性的作用。
6. Interactions between cyclosporin A indomethacin and 1616-dimethyl prostaglandin E2: effects on renal hepatic and gastrointestinal toxicity in the rat. [O] . P. H. Whiting, N. Barnard, A. Neilsch, 1987

机译：环孢菌素A吲哚美辛和1616-二甲基前列腺素E2之间的相互作用：对大鼠肾脏肝脏和胃肠道毒性的影响。
7. Experimental nephrotoxicity, hepatotoxicity and pharmacokinetics of cyclosporin G versus cyclosporin A [O] . Burdmann Emmanuel A., Andoh Takeshi F., Rosen Seymour, 1994

机译：环孢菌素G与环孢菌素A的实验肾毒性，肝毒性和药代动力学
8. Association between Cyclosporin Neurotoxicity and Hypomagnesaemia [R] . Thompson, C. B., June, C. H., Sullivan, K. M., 1984

机译：环孢菌素神经毒性与低氧血症的关系

Juvenile toxicity of cyclosporin in the rat.

摘要

著录项

相似文献

相关主题

期刊订阅