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首页> 外文期刊>Reproductive toxicology >Developmental toxicity of albendazole and its three main metabolites in zebrafish embryos.
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Developmental toxicity of albendazole and its three main metabolites in zebrafish embryos.

机译：阿苯达唑及其三种主要代谢产物在斑马鱼胚胎中的发育毒性。

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摘要

Albendazole (ABZ) is used as an anthelmintic drug in humans and animals. ABZ has been shown to cause developmental toxicity in experimental animals, however it is not clear if this is caused by the parent compound or a metabolite. Zebrafish embryos were exposed from 1 to 144hpf (hours post fertilization) to investigate the developmental toxicity of ABZ, the first metabolite albendazole sulphoxide and the subsequent metabolites albendazole sulphone (ABZSO(2)) and albendazole-2-aminosulphone (ABZSO(2)NH(2)). The results showed that ABZ caused malformations of head and tail and embryonic lethality from 0.3muM. In contrast, the metabolites did not display developmental toxicity at any tested concentration. Dechorionation did not influence the developmental toxic potential of ABZ and ABZSO, indicating that bioavailability was not a limiting factor. Chemical analysis showed that at sublethal concentrations, most of ABZ was metabolized to ABZSO. The results demonstrate that in zebrafish embryos ABZ rather than ABZSO displays developmental toxicity.
机译：阿苯达唑（ABZ）在人和动物中用作驱虫药。已显示ABZ在实验动物中引起发育毒性，但是尚不清楚这是由母体化合物还是代谢产物引起的。斑马鱼胚胎暴露于1至144hpf（受精后数小时）以研究ABZ，第一个代谢产物阿苯达唑亚砜和随后的代谢产物阿苯达唑砜（ABZSO（2））和阿苯达唑-2-氨基砜（ABZSO（2）NH）的发育毒性（2））。结果表明，ABZ从0.3μM起引起头，尾畸形和胚胎致死率。相反，在任何测试浓度下，代谢物均未显示出发育毒性。脱壳作用不影响ABZ和ABZSO的发育毒性潜力，表明生物利用度不是限制因素。化学分析表明，在致死浓度下，大部分ABZ代谢为ABZSO。结果表明，在斑马鱼胚胎中，ABZ而非ABZSO表现出发育毒性。

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